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晚期肝细胞癌的新治疗选择。

New Therapeutic Options for Advanced Hepatocellular Carcinoma.

机构信息

Cancer Institute, 377323Nantong Tumor Hospital, Nantong, China.

Department of Radiology, 12485The Forth Affiliated Hospital of Anhui Medical University, Hefei, China.

出版信息

Cancer Control. 2020 Jul-Aug;27(3):1073274820945975. doi: 10.1177/1073274820945975.

Abstract

Hepatocellular carcinoma (HCC), one of the most common lethal diseases in the world, has a 5-year survival rate of only 7%. Hepatocellular carcinoma has no symptoms in the early stage but obvious symptoms in the late stage, leading to delayed diagnosis and reduced treatment efficacy. In recent years, as the scope of HCC research has increased in depth, the clinical development and application of molecular targeted drugs and immunotherapy drugs have brought new breakthroughs in HCC treatment. Targeted therapy drugs for HCC have high specificity, allowing them to selectively kill tumor cells and minimize damage to normal tissues. At present, these targeted drugs are mainly classified into 3 categories: small molecule targeted drugs, HCC antigen-specific targeted drugs, and immune checkpoint targeted drugs. This article reviews the latest research progress on the targeted drugs for HCC.

摘要

肝细胞癌(HCC)是世界上最常见的致命疾病之一,其 5 年生存率仅为 7%。HCC 在早期阶段没有症状,但在晚期阶段症状明显,导致诊断延迟和治疗效果降低。近年来,随着 HCC 研究范围的深入,分子靶向药物和免疫治疗药物的临床发展和应用在 HCC 治疗方面带来了新的突破。HCC 的靶向治疗药物具有高度特异性,能够选择性地杀死肿瘤细胞,最大限度地减少对正常组织的损伤。目前,这些靶向药物主要分为 3 类:小分子靶向药物、HCC 抗原特异性靶向药物和免疫检查点靶向药物。本文综述了 HCC 靶向药物的最新研究进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8655/7791453/ee646b8080c2/10.1177_1073274820945975-fig1.jpg

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