Kresina T F, Yoo J U, Goldberg V M
Department of Medicine, Case Western Reserve University, Cleveland, Ohio.
Arthritis Rheum. 1988 Feb;31(2):248-57. doi: 10.1002/art.1780310213.
We examined antiproteoglycan antibodies as an autoimmune response for induction of synovitis. This hypothesis was studied by monitoring humoral antiproteoglycan antibody following IgG induction of experimental immune synovitis, localization in the articular cartilage of an autologous immune response, and loss of proteoglycan from cartilage following intravenous administration of antiproteoglycan monoclonal antibodies. The data support the hypothesis that autoimmunity to cartilage macromolecules may play a role in the etiopathogenesis of arthritis.
我们检测了抗蛋白聚糖抗体作为诱导滑膜炎的自身免疫反应。通过在实验性免疫性滑膜炎的IgG诱导后监测体液中的抗蛋白聚糖抗体、自体免疫反应在关节软骨中的定位以及静脉注射抗蛋白聚糖单克隆抗体后软骨中蛋白聚糖的丢失，对这一假设进行了研究。数据支持了软骨大分子自身免疫可能在关节炎的发病机制中起作用这一假设。
