Zhang Yu, He Jian, Chen Hechun, Xiong Chengdong
26444Chengdu Institute of Organic Chemistry CAS, Chengdu, China.
J Biomater Appl. 2021 Jan;35(6):720-731. doi: 10.1177/0885328220949376. Epub 2020 Aug 16.
Ureteral stents have been widely used as biomedical devices to treat some urological diseases for several decades. However, the encrustation complications hamper the long-time clinical use of the ureteral stents. In this work, a new type of biodegradable material for the ureteral stents, methoxypoly(ethylene glycol)-block-poly(L-lactide-ran-Ɛ-caprolactone) (mPEG-PLACL), is evaluated to overcome this problem. The results show that the hydrophilicity and degradation rate in artificial urine of mPEG-PLACL are both significantly increased. It is worth noting that the mPEG-PLACL shows a lower amount of encrustation after immersing the stents in the dynamic urinary extracorporeal circulation (DUEC) model for 7 days. In addition, 71% Ca and 92% Mg are inhibited by quantitative analysis. Pathological analysis exhibit that the mPEG-PLACL cause less diffuse mucosal hyperplasia after 7 weeks of implantation. All the results indicate that this new type of biodegradable material had an excellent potential for the ureteral stents in the future.
几十年来，输尿管支架作为一种生物医学装置被广泛用于治疗一些泌尿系统疾病。然而，结壳并发症阻碍了输尿管支架的长期临床应用。在这项工作中，一种新型的用于输尿管支架的可生物降解材料，甲氧基聚（乙二醇）-嵌段-聚（L-丙交酯-无规-ε-己内酯）（mPEG-PLACL），被评估以克服这个问题。结果表明，mPEG-PLACL在人工尿液中的亲水性和降解速率均显著提高。值得注意的是，将支架在动态体外尿液循环（DUEC）模型中浸泡7天后，mPEG-PLACL的结壳量较低。此外，通过定量分析发现，71%的钙和92%的镁被抑制。病理分析表明，植入7周后，mPEG-PLACL引起的弥漫性黏膜增生较少。所有结果表明，这种新型可生物降解材料在未来用于输尿管支架方面具有巨大潜力。
