Department of Morphology, Surgery, and Experimental Medicine, University of Ferrara, 44121 Ferrara, Italy.
Department of Surgery, University of Verona, 37129 Verona, Italy.
Int J Mol Sci. 2019 Jan 31;20(3):618. doi: 10.3390/ijms20030618.
The regenerative medicine, a new discipline that merges biological sciences and the fundamental of engineering to develop biological substitutes, has greatly benefited from recent advances in the material engineering and the role of stem cells in tissue regeneration. Regenerative medicine strategies, involving the combination of biomaterials/scaffolds, cells, and bioactive agents, have been of great interest especially for the repair of damaged bone and bone regrowth. In the last few years, the life expectancy of our population has progressively increased. Aging has highlighted the need for intervention on human bone with biocompatible materials that show high performance for the regeneration of the bone, efficiently and in a short time. In this review, the different aspects of tissue engineering applied to bone engineering were taken into consideration. The first part of this review introduces the bone cellular biology/molecular genetics. Data on biomaterials, stem cells, and specific growth factors for the bone regrowth are reported in this review.
再生医学是一门新兴学科，它融合了生物科学和工程学的基本原理，以开发生物替代品。它极大地受益于材料工程的最新进展和干细胞在组织再生中的作用。再生医学策略，包括生物材料/支架、细胞和生物活性物质的结合，特别受到关注，特别是用于修复受损骨骼和促进骨再生。在过去的几年中，我们的人口预期寿命逐渐增加。随着年龄的增长，人们对具有生物相容性的材料进行干预以修复人体骨骼的需求变得尤为迫切，这些材料在高效和短时间内具有出色的骨骼再生性能。在这篇综述中，考虑了组织工程在骨骼工程中的不同方面。这篇综述的第一部分介绍了骨骼细胞生物学/分子遗传学。本文报道了生物材料、干细胞和特定的生长因子在骨再生中的数据。
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