Usami H, Yamamoto A, Yamashita W, Sugawara Y, Hamada S, Yamamoto T, Kato K, Kokeguchi S, Ohokuni H, Kotani S
Applied Research Laboratories, Chugai Pharmaceutical Co., Ltd., Tokyo, Japan.
Br J Cancer. 1988 Jan;57(1):70-3. doi: 10.1038/bjc.1988.11.
The antitumour effects of lipoteichoic acids (LTA) extracted from Streptococcus pyogenes were studied in comparison with other streptococcal cellular components. LTA suppressed the tumour growth of both solid- and ascites-type Meth A fibrosarcoma as did the whole cells of S. pyogenes (OK-432). No other cellular components, such as cell wall peptidoglycan, group-specific C-carbohydrate or type-specific M protein, suppressed the growth of Meth A. LTA, but not the other cellular components, induced tumour necrosis factor (TNF) in Propionibacterium acnes-primed mice. LTA had no direct killing effects on Meth A cells. These results indicate that LTA may be an important antitumour component of OK-432 and that one of the antitumour mechanisms by this streptococcal preparation is the induction of TNF.
对从化脓性链球菌中提取的脂磷壁酸（LTA）的抗肿瘤作用进行了研究，并与其他链球菌细胞成分进行了比较。LTA抑制实体型和腹水型Meth A纤维肉瘤的肿瘤生长，化脓性链球菌（OK-432）的全细胞也有此作用。没有其他细胞成分，如细胞壁肽聚糖、群特异性C碳水化合物或型特异性M蛋白，能抑制Meth A的生长。LTA而非其他细胞成分，在痤疮丙酸杆菌致敏的小鼠中诱导肿瘤坏死因子（TNF）。LTA对Meth A细胞没有直接杀伤作用。这些结果表明，LTA可能是OK-432的一种重要抗肿瘤成分，并且这种链球菌制剂的抗肿瘤机制之一是诱导TNF。
