Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore, 560012, India.
Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore, 560012, India.
Eur J Cell Biol. 2020 Aug;99(6):151099. doi: 10.1016/j.ejcb.2020.151099. Epub 2020 Jul 2.
The serine/arginine rich proteins (SR proteins) are members of a family of RNA binding proteins involved in regulating various features of RNA metabolism, including pre-mRNA constitutive and alternative splicing. In humans, a total of 12 SR splicing factors (SRSFs) namely SRSF1-SRSF12 have been reported. SRSF3, the smallest member of the SR family and the focus of this review, regulates critical steps in mRNA metabolism and has been shown to have mRNA-independent functions as well. Recent studies on SRSF3 have uncovered its role in a wide array of complex biological processes. We have also reviewed the involvement of SRSF3 in disease conditions like cancer, ageing, neurological and cardiac disorders. Finally, we have discussed in detail the autoregulation of SRSF3 and its implications in cancer and commented on the potential of SRSF3 as a therapeutic target, especially in the context of cancer.
丝氨酸/精氨酸丰富蛋白（SR 蛋白）是 RNA 结合蛋白家族的成员，参与调节 RNA 代谢的各种特征，包括前体 mRNA 的组成性和选择性剪接。在人类中，已报道了总共 12 种 SR 剪接因子（SRSFs），即 SRSF1-SRSF12。SRSF3 是 SR 家族中最小的成员，也是本综述的重点，它调节 mRNA 代谢的关键步骤，并且已经显示出具有与 mRNA 无关的功能。最近对 SRSF3 的研究揭示了它在广泛的复杂生物学过程中的作用。我们还综述了 SRSF3 在疾病条件如癌症、衰老、神经和心脏疾病中的作用。最后，我们详细讨论了 SRSF3 的自我调节及其在癌症中的意义，并评论了 SRSF3 作为治疗靶点的潜力，特别是在癌症的背景下。
