Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, Hunan, China.
Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, Hunan, China; Hunan Provincial Key Laboratory of clinical epidemiology, Changsha, Hunan, China.
Int J Cardiol. 2021 Jan 1;322:121-128. doi: 10.1016/j.ijcard.2020.08.018. Epub 2020 Aug 13.
Although it is generally acknowledged that genetic and environmental factors are associated with risk of congenital heart disease (CHD), the causes are not fully understood. This study aimed at assessing the association of maternal dietary intakes, genetic variants of cystathionine beta synthase (CBS) gene and their interactions with risk of CHDs in offspring.
A hospital-based case-control study of 464 mothers with CHD infants and 504 control mothers of health infant was performed. The exposures of interest were maternal dietary intakes in early pregnancy, single nucleotide polymorphisms (SNPs) of CBS gene.
More frequent intake of pickled vegetables (adjusted odds ratio[aOR] = 1.81; 95% confidence interval[CI]: 1.38-2.37), smoked foods (aOR = 2.00; 95%CI: 1.53-2.60), barbecued foods (aOR = 1.63; 95%CI: 1.19-2.25) and fried foods (aOR = 1.57; 95%CI: 1.22-2.03) were associated with higher risk of CHD, while salted eggs (aOR = 0.20; 95%CI: 0.12-0.33), fish and shrimp (aOR = 0.34; 95%CI: 0.27-0.44), fresh fruits (aOR = 0.49; 95%CI: 0.37-0.66), and milk products (aOR = 0.54; 95%CI: 0.45-0.65) were associated with lower risk of CHD. The SNPs of CBS gene at rs2851391 (T/T vs C/C: aOR = 1.91, 95%CI: 1.15-3.15) and rs234714 (T/T vs C/C: aOR = 2.22, 95%CI: 1.32-3.73) significantly increased the risk of CHD. Additionally, significant interaction effects between maternal dietary intakes and CBS genetic variants on CHD risks were observed.
Maternal dietary factors, CBS genetic variants and their interactions were significantly associated with risk of CHD in offspring. However, it is still unclear how these factors jointly work in the development of CHD, and more studies with larger samples and prospective design are required.
尽管人们普遍认为遗传和环境因素与先天性心脏病（CHD）的风险相关，但病因尚不完全清楚。本研究旨在评估母体膳食摄入、胱硫醚β合酶（CBS）基因的遗传变异及其与后代 CHD 风险的相互作用。
对 464 名患有 CHD 婴儿的母亲和 504 名健康婴儿的对照母亲进行了基于医院的病例对照研究。感兴趣的暴露因素是母亲在妊娠早期的膳食摄入、CBS 基因的单核苷酸多态性（SNP）。
频繁食用腌制蔬菜（调整后的优势比[aOR] = 1.81；95%置信区间[CI]：1.38-2.37）、熏制食品（aOR = 2.00；95%CI：1.53-2.60）、烧烤食品（aOR = 1.63；95%CI：1.19-2.25）和油炸食品（aOR = 1.57；95%CI：1.22-2.03）与 CHD 风险增加相关，而咸蛋（aOR = 0.20；95%CI：0.12-0.33）、鱼和虾（aOR = 0.34；95%CI：0.27-0.44）、新鲜水果（aOR = 0.49；95%CI：0.37-0.66）和奶制品（aOR = 0.54；95%CI：0.45-0.65）与 CHD 风险降低相关。CBS 基因的 SNPs rs2851391（T/T 与 C/C：aOR = 1.91，95%CI：1.15-3.15）和 rs234714（T/T 与 C/C：aOR = 2.22，95%CI：1.32-3.73）显著增加了 CHD 的风险。此外，还观察到母体膳食摄入和 CBS 遗传变异之间存在显著的交互作用，对 CHD 风险的影响。
母体膳食因素、CBS 遗传变异及其相互作用与后代 CHD 风险显著相关。然而，这些因素如何共同作用于 CHD 的发生尚不清楚，还需要更多具有更大样本量和前瞻性设计的研究。
