Universal Council of Epidemiology (UCE), Universal Scientific Education and Research Network (USERN), Tehran University of Medical Sciences, Tehran, Iran.
Universal Council of Epidemiology (UCE), Universal Scientific Education and Research Network (USERN), Tehran University of Medical Sciences, Tehran, Iran.
Autoimmun Rev. 2020 Oct;19(10):102650. doi: 10.1016/j.autrev.2020.102650. Epub 2020 Aug 13.
To assess the pooled risk of cancer in patients with multiple sclerosis.
We searched PubMed, Scopus, EMBASE, Web of Science, Ovid, google scholar and gray literature (references of studies, conference abstracts) which were published up to September 2019. The search strategy included the MeSH and text words as ((cancer) OR tumor) OR neoplasm) OR "malignant neoplasm) OR "benign neoplasm) AND (Multiple Sclerosis OR Sclerosis, Multiple) OR Sclerosis, Disseminated) OR Disseminated Sclerosis) OR MS (Multiple Sclerosis)) OR Multiple Sclerosis, Acute Fulminating).
The first literature search revealed 18,996 articles. After deletion of duplicate articles, finally, 264 articles remained. Excluding non-relevant articles, resulted in including 5 articles which met inclusion criteria. The RR estimated between 0.7 and 1.67 in included articles. The pooled RR estimated as 0.83 (95% CI:0.73-0.96) (I = 90%, P < 0.001). Two studies provided prevalence of different cancers. The pooled prevalence of breast cancer in two studies was 2% (95%CI:2%-2%) (I = 0%). The pooled prevalence of digestive system cancer in two studies was 2% (95%CI:1%-2%) (I = 0%). The pooled prevalence of skin cancer in two studies was 1% (95%CI:0%-1%) (I = 0).
The result of this systematic review showed that the risk of cancer in patients with MS is less than the general population.
评估多发性硬化症患者癌症的发病风险。
我们检索了 PubMed、Scopus、EMBASE、Web of Science、Ovid、谷歌学术和灰色文献（研究参考文献、会议摘要），检索时间截至 2019 年 9 月。检索策略包括 MeSH 和文本词，如((癌症)或肿瘤)或新生物)或“恶性新生物)或“良性新生物)和(多发性硬化症或多发性硬化症)或硬化症，多发性)或播散性硬化症)或 MS (多发性硬化症))或多发性硬化症，急性暴发性)。
第一次文献检索显示有 18996 篇文章。删除重复文章后，最终有 264 篇文章保留下来。排除不相关的文章后，有 5 篇文章符合纳入标准。纳入文章估计的 RR 值在 0.7 至 1.67 之间。汇总的 RR 估计值为 0.83(95%CI：0.73-0.96)(I = 90%，P < 0.001)。两项研究提供了不同癌症的患病率。两项研究中乳腺癌的汇总患病率为 2%(95%CI：2%-2%)(I = 0%)。两项研究中消化系统癌症的汇总患病率为 2%(95%CI：1%-2%)(I = 0%)。两项研究中皮肤癌的汇总患病率为 1%(95%CI：0%-1%)(I = 0%)。
本系统评价的结果表明，多发性硬化症患者的癌症风险低于一般人群。
