Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA.
Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA; Purdue Institute of Inflammation, Immunology, and Infectious Disease, Purdue University, West Lafayette, IN 47907, USA.
Curr Opin Virol. 2020 Dec;45:51-64. doi: 10.1016/j.coviro.2020.07.006. Epub 2020 Aug 13.
Flaviviruses are emerging arthropod-borne RNA viruses, causing a broad spectrum of life-threatening disease symptoms such as encephalitis and hemorrhagic fever. Successful vaccines exist against yellow fever virus, Japanese encephalitis virus and tick-borne encephalitis virus. However, vaccine development against other flaviviruses like dengue virus is not straightforward. This is partly because of the high sequence conservation and immunological cross-reactivity among flavivirus envelope glycoproteins leading to antibody mediated enhancement of disease. A comprehensive analyses of the structural landscape of humoral immune response against flaviviruses is crucial for antigen design. Here, we compare the available structural data of several flavivirus antibody complexes with a major focus on Zika virus and dengue virus and discuss the mapped epitopes, the stoichiometry of antibody binding and mechanisms of neutralization.
黄病毒是新兴的节肢动物传播的 RNA 病毒，可引起广泛的危及生命的疾病症状，如脑炎和出血热。针对黄热病病毒、日本脑炎病毒和蜱传脑炎病毒已有成功的疫苗。然而，针对登革热病毒等其他黄病毒的疫苗开发并不简单。这部分是因为黄病毒包膜糖蛋白之间存在高度的序列保守性和免疫交叉反应性，导致抗体介导的疾病加重。全面分析针对黄病毒的体液免疫反应的结构景观对于抗原设计至关重要。在这里，我们比较了几种黄病毒抗体复合物的现有结构数据，重点是寨卡病毒和登革热病毒，并讨论了映射的表位、抗体结合的化学计量和中和机制。
