Baric Thomas J, Reneer Z Beau
Department of Epidemiology, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3500, USA.
Viruses. 2024 Dec 24;17(1):1. doi: 10.3390/v17010001.
Flaviviruses are arthropod-borne viruses primarily transmitted through the mosquito or genus of mosquitos. These viruses are predominantly found in tropical and subtropical regions of the world with their geographical spread predicted to increase as global temperatures continue to rise. These viruses cause a variety of diseases in humans with the most prevalent being caused by dengue, resulting in hemorrhagic fever and associated sequala. Current approaches for therapeutic control of flavivirus infections are limited, and despite recent advances, there are no approved drugs. Vaccines, available for a few circulating flaviviruses, still have limited potential for controlling contemporary and future outbreaks. Mouse models provide us with a valuable tool to test the effectiveness of drugs and vaccines, yet for many flaviviruses, well-established mouse models are lacking. In this review, we highlight the current state of flavivirus vaccines and therapeutics, as well as our current understanding of mouse models for various flaviviruses.
黄病毒是节肢动物传播的病毒，主要通过蚊子或特定蚊属传播。这些病毒主要分布在世界热带和亚热带地区，预计随着全球气温持续上升，其地理分布范围还会扩大。这些病毒可导致人类多种疾病，其中最常见的是由登革热引起的，会导致出血热及相关后遗症。目前针对黄病毒感染的治疗控制方法有限，尽管最近有进展，但仍没有获批药物。针对少数几种流行的黄病毒有可用疫苗，但其在控制当前及未来疫情方面的潜力仍然有限。小鼠模型为我们提供了测试药物和疫苗有效性的宝贵工具，但对于许多黄病毒来说，缺乏成熟的小鼠模型。在本综述中，我们重点介绍了黄病毒疫苗和治疗方法的现状，以及我们目前对各种黄病毒小鼠模型的了解。
