Schmidt D, Ferrandes B, Grandjean D, Gugler R, Jakobs C, Johannessen S, Klotz U, Kochen W, Kupferberg H J, Meijer J W, Richens A, Schäfer H, Schulz H U, Windorfer A
Arzneimittelforschung. 1977;27(5):1078-81.
19 pooled plasma specimens were sent as unknowns to 13 participating research laboratories. The interlaboratory variability between the results was very high. Only 4 out of 13 laboratories had 6--12% of their results within the 95% confidence limit for each sample. The precision of repeated determinations was fairly good. 6 out of 10 participating laboratories had a coefficient of variation of less then 5%. The reproducibility and the agreement between the different procedures for quantitative analysis of dipropylacetate is similar to that reported for other major antiepileptic drugs.
19份混合血浆标本作为未知样本被送往13个参与研究的实验室。各实验室结果之间的实验室间变异性非常高。13个实验室中只有4个实验室，其每个样本的6%-12%的结果在95%置信区间内。重复测定的精密度相当好。10个参与实验室中有6个实验室的变异系数小于5%。双丙戊酸定量分析不同方法之间的重现性和一致性与其他主要抗癫痫药物报道的情况相似。
