Peat M A
Clinical and Forensic Services, ChemWest Analytical Laboratories, Inc., Sacramento, CA.
Clin Chem. 1988 Mar;34(3):471-3.
Many laboratories are now performing urine drug testing for employers, governmental agencies, and other institutions. It is now recognized that presumptive positive screening results have to be confirmed by an analytical procedure based on a different chemical technique with greater than or equal sensitivity to the screening test. Thin-layer chromatography has been widely used for this; however, it is relatively insensitive for certain drugs, and it cannot satisfy the accuracy and precision requirements needed to determine threshold concentrations reliably. Gas chromatography-mass spectrometry is able to satisfy these threshold requirements and has become the method of choice for confirming initial immunoassay results.
现在，许多实验室都在为雇主、政府机构和其他机构进行尿液药物检测。目前人们认识到，推定的阳性筛查结果必须通过一种基于不同化学技术的分析程序来确认，该技术的灵敏度要大于或等于筛查测试。薄层色谱法已被广泛用于此；然而，它对某些药物相对不敏感，并且无法满足可靠确定阈值浓度所需的准确性和精密度要求。气相色谱-质谱联用技术能够满足这些阈值要求，并已成为确认初始免疫分析结果的首选方法。
