Fekadu Ginenus, Bekele Firomsa, Bekele Kumera, Girma Tsiyon, Mosisa Getu, Gebre Mohammed, Alemu Tamirat, Tekle Tesfa, Gamachu Busha, Diriba Amenu
Department of Pharmacy, Institute of Health Science, Wollega University, Nekemte, Ethiopia.
Department of Pharmacy, College of Health Science, Mettu University, Mettu, Ethiopia.
Patient Prefer Adherence. 2020 Jul 24;14:1259-1265. doi: 10.2147/PPA.S258292. eCollection 2020.
Non-adherence to tuberculosis treatment is the most challenging and hindering factor for successful tuberculosis therapy. The long duration of tuberculosis treatment and the undesirable effects of anti-tuberculosis drugs result in non-adherence to treatment among pediatric patients. Hence, this study was aimed to evaluate pediatrics adherence status among tuberculosis pediatric patients on anti-tuberculosis treatment at Nekemte Specialized Hospital.
A health facility-based cross-sectional study design was used to recruit pediatric TB patients who were receiving their treatment between February 15 and March 15, 2019. Adherence to tuberculosis therapy was evaluated using data obtained from face-to-face interviews of their respective caregivers. The collected data were entered into EPI-manager 4.0.2 software and analyzed using SPSS version 24. Logistic regression was used to analyze the variables and variables with p-value <0.05 had a statistically significant association with the adherence to anti TB treatment.
Among 202 participants involved in the study, 120 (59.4%) of them were males and 119 (58.9%) were in the age category of 11-15 years. A total of 166 (82.2%) of the patients had extra-pulmonary tuberculosis and 174 (86.1%) of them were in the intensive phase. Of the pediatric tuberculosis patients, 48 (73.3%) of them have adhered to the treatment regimen. Female gender [AOR: 3.3, 95% CI: 1.52-7.2], younger age (0-5 years) [AOR: 5.96 95% CI: 1.81-19.6], living in urban area [AOR: 3.73, 95% CI: 1.67-8.36], and patients who did not experience side effect [AOR: 2.87, 95% CI: 1.41-5.81] were predictors of good adherence to tuberculosis treatment up on multivariable logistic regression analysis.
The level of adherence observed in our study area was low. Age, sex, residence, and side effect experience showed an association with tuberculosis treatment adherence. Therefore, health care providers should educate all patients with tuberculosis before the initiation of anti-tuberculosis treatment.
不坚持结核病治疗是成功治疗结核病最具挑战性和阻碍性的因素。结核病治疗疗程长以及抗结核药物的不良作用导致儿科患者不坚持治疗。因此，本研究旨在评估内克姆特专科医院接受抗结核治疗的结核病儿科患者的依从性状况。
采用基于医疗机构的横断面研究设计，招募在2019年2月15日至3月15日期间接受治疗的儿科结核病患者。通过对其各自照顾者进行面对面访谈获得的数据来评估结核病治疗的依从性。收集的数据录入EPI - manager 4.0.2软件，并使用SPSS 24版进行分析。采用逻辑回归分析变量，p值<0.05的变量与抗结核治疗依从性具有统计学显著关联。
在参与研究的202名参与者中，120名（59.4%）为男性，119名（58.9%）年龄在11 - 15岁之间。共有166名（82.2%）患者患有肺外结核病，其中174名（86.1%）处于强化期。在儿科结核病患者中，48名（73.3%）坚持了治疗方案。多变量逻辑回归分析显示，女性[AOR：3.3，95% CI：1.52 - 7.2]、年龄较小（0 - 5岁）[AOR：5.96，95% CI：1.81 - 19.6]、居住在城市地区[AOR：3.73，95% CI：1.67 - 8.36]以及未经历副作用的患者[AOR：2.87，95% CI：1.41 - 5.81]是结核病治疗依从性良好的预测因素。
我们研究区域观察到的依从水平较低。年龄、性别、居住地点和副作用经历与结核病治疗依从性相关。因此，医疗保健提供者应在开始抗结核治疗前对所有结核病患者进行教育。
