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大规模分析揭示了DGCR5在胶质瘤中的特定临床和免疫特征。

Large-Scale Analysis Reveals the Specific Clinical and Immune Features of DGCR5 in Glioma.

作者信息

Wu Xuechao, Hou Peng, Qiu Yun, Wang Qing, Lu Xiaojie

机构信息

Department of Neurosurgery, The Affiliated Wuxi No.2 People's Hospital of Nanjing Medical University, Wuxi, People's Republic of China.

出版信息

Onco Targets Ther. 2020 Jul 31;13:7531-7543. doi: 10.2147/OTT.S257050. eCollection 2020.

DOI:10.2147/OTT.S257050
PMID:32801772
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7402863/
Abstract

PURPOSE

Long non-coding RNA DGCR5 plays different roles in different types of cancer. The purpose of this study was to investigate the clinicopathological features, potential biological functions and prognostic significance of DGCR5 in glioma in a large-scale study.

MATERIALS AND METHODS

A total of 697 RNA-seq data from The Cancer Genome Atlas (TCGA) and 301 mRNA microarray data from Chinese Glioma Genome Atlas (CGGA) were enrolled in this study. R language was used as the main tool for statistical analysis and graphical work.

RESULTS

DGCR5 showed a negative correlation with the WHO grade of malignancy in glioma. Specifically, DGCR5 expression was significantly decreased in GBM and IDH wild-type glioma. Gene ontology analysis showed that DGCR5 was predominantly enriched in immune-related biological processes. Additionally, DGCR5 showed a significant correlation with stromal and immune cell populations, inflammatory activities and immune checkpoints. Clinically, patients with low-expression level of DGCR5 exhibited a worse overall survival.

CONCLUSION

DGCR5 expression is downregulated in glioma, and low DGCR5 independently predicts worse prognosis in glioma patients. Moreover, DGCR5 is significantly associated with immune response and immune infiltration. These findings suggest that DGCR5 is a promising immunotherapy target and a novel prognostic biomarker for glioma.

摘要

目的

长链非编码RNA DGCR5在不同类型的癌症中发挥着不同的作用。本研究旨在通过大规模研究探讨DGCR5在胶质瘤中的临床病理特征、潜在生物学功能及预后意义。

材料与方法

本研究纳入了来自癌症基因组图谱（TCGA）的697个RNA测序数据和来自中国胶质瘤基因组图谱（CGGA）的301个mRNA微阵列数据。R语言用作统计分析和图形处理的主要工具。

结果

DGCR5与胶质瘤的世界卫生组织恶性程度分级呈负相关。具体而言，在胶质母细胞瘤（GBM）和异柠檬酸脱氢酶（IDH）野生型胶质瘤中，DGCR5表达显著降低。基因本体分析表明，DGCR5主要富集于免疫相关的生物学过程。此外，DGCR5与基质和免疫细胞群体、炎症活动及免疫检查点显著相关。临床上，DGCR5低表达的患者总生存期较差。

结论

DGCR5在胶质瘤中表达下调，低表达的DGCR5可独立预测胶质瘤患者预后较差。此外，DGCR5与免疫反应和免疫浸润显著相关。这些发现表明，DGCR5是一种有前景的免疫治疗靶点和新型的胶质瘤预后生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8903/7402863/560c4926e69b/OTT-13-7531-g0008.jpg
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本文引用的文献

1
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2
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Eur Rev Med Pharmacol Sci. 2019 Nov;23(22):10024-10034. doi: 10.26355/eurrev_201911_19569.
3
Is a Prognostic Biomarker and Correlates With Stromal and Immune Infiltration in Gliomas.
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Metab Brain Dis. 2024 Feb;39(2):313-320. doi: 10.1007/s11011-023-01316-1. Epub 2023 Nov 14.
4
Development of a novel angiogenesis-related lncRNA signature to predict the prognosis and immunotherapy of glioblastoma multiforme.开发一种新型血管生成相关lncRNA特征以预测多形性胶质母细胞瘤的预后和免疫治疗效果。
Transl Cancer Res. 2023 Jan 30;12(1):13-30. doi: 10.21037/tcr-22-1592. Epub 2022 Dec 22.
5
Glioblastoma-derived extracellular vesicle subpopulations following 5-aminolevulinic acid treatment bear diagnostic implications.经 5-氨基酮戊酸处理后的神经胶质瘤衍生细胞外囊泡亚群具有诊断意义。
J Extracell Vesicles. 2022 Nov;11(11):e12278. doi: 10.1002/jev2.12278.
6
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Front Immunol. 2022 Aug 12;13:932938. doi: 10.3389/fimmu.2022.932938. eCollection 2022.
7
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8
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Medicine (Baltimore). 2021 Apr 23;100(16):e25603. doi: 10.1097/MD.0000000000025603.
9
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4
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Int J Cancer. 2020 Jan 15;146(2):424-438. doi: 10.1002/ijc.32533. Epub 2019 Jul 13.
5
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7
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8
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9
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