Xue Chen, Chen Can, Gu Xinyu, Li Lanjuan
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University Hangzhou 310003, China.
Am J Cancer Res. 2021 Jan 1;11(1):1-13. eCollection 2021.
As a special type of noncoding RNA, long noncoding RNAs (lncRNAs) have vital roles during the development of human cancers and may be novel predictors or therapeutic targets for improving the management of patients with cancer. DiGeorge syndrome critical region gene 5 () is a prominent tumor-associated lncRNA, exerting tumor suppressor or oncogenic roles in various cancers. Previous studies have reported that has low expression in most types of cancers but high expression in triple-negative breast cancer, gallbladder cancer, and lung cancer. And expression is related to many hallmarks of cancer types, including cell proliferation, invasion, migration, apoptosis, stemness, and therapeutic responsiveness. Additionally, the pivotal molecules involved in DGCR5 regulation of signaling pathways are attributed to cancer hallmarks related to the pathogenesis of different types of malignant tumors. Herein, we discuss the DGCR5 expression pattern in various types of tumor tissues and relationships between DGCR5 expression and immune cell infiltration and immune purity. We also review our current understanding of DGCR5 in carcinogenesis and its potential application as a prognostic biomarker or therapeutic target in human cancers.
作为一种特殊类型的非编码RNA，长链非编码RNA（lncRNAs）在人类癌症发生发展过程中发挥着重要作用，可能是改善癌症患者管理的新型预测指标或治疗靶点。狄乔治综合征关键区域基因5（DGCR5）是一种显著的肿瘤相关lncRNA，在多种癌症中发挥抑癌或致癌作用。既往研究报道，DGCR5在大多数癌症类型中表达较低，但在三阴性乳腺癌、胆囊癌和肺癌中表达较高。并且DGCR5的表达与癌症类型的许多特征相关，包括细胞增殖、侵袭、迁移、凋亡、干性和治疗反应性。此外，DGCR5调控信号通路所涉及的关键分子与不同类型恶性肿瘤发病机制相关的癌症特征有关。在此，我们讨论DGCR5在各种肿瘤组织中的表达模式以及DGCR5表达与免疫细胞浸润和免疫纯度之间的关系。我们还综述了目前对DGCR5在致癌作用中的认识及其作为人类癌症预后生物标志物或治疗靶点的潜在应用。
