Zhu Hongyuan, Yang Haiqian, Ma Yufei, Lu Tian Jian, Xu Feng, Genin Guy M, Lin Min
The Key Laboratory of Biomedical Information Engineering of Ministry of Education School of Life Science and Technology Xi'an Jiaotong University Xi'an 710049 P. R. China.
Bioinspired Engineering & Biomechanics Center (BEBC) Xi'an Jiaotong University Xi'an 710049 P. R. China.
Adv Funct Mater. 2020 Aug 7;30(32):2000639. doi: 10.1002/adfm.202000639. Epub 2020 Jun 18.
Photoresponsive hydrogels (PRHs) are soft materials whose mechanical and chemical properties can be tuned spatially and temporally with relative ease. Both photo-crosslinkable and photodegradable hydrogels find utility in a range of biomedical applications that require tissue-like properties or programmable responses. Progress in engineering with PRHs is facilitated by the development of theoretical tools that enable optimization of their photochemistry, polymer matrices, nanofillers, and architecture. This review brings together models and design principles that enable key applications of PRHs in tissue engineering, drug delivery, and soft robotics, and highlights ongoing challenges in both modeling and application.
光响应水凝胶（PRHs）是一种软材料，其机械和化学性质能够相对容易地在空间和时间上进行调节。可光交联和可光降解的水凝胶在一系列需要类似组织特性或可编程响应的生物医学应用中都有实用价值。用于PRHs的理论工具的发展推动了其工程学方面的进展，这些工具能够优化其光化学、聚合物基质、纳米填料和结构。本综述汇集了一些模型和设计原则，这些原则实现了PRHs在组织工程、药物递送和软机器人领域的关键应用，并突出了建模和应用方面目前面临的挑战。
