Yao Hongyi, Wang Jieqiong, Mi Shengli
Biomanufacturing Engineering Laboratory, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China.
Open FIESTA Center, Tsinghua University, Shenzhen 518055, China.
Polymers (Basel). 2017 Dec 22;10(1):11. doi: 10.3390/polym10010011.
A large number of opportunities for biomedical hydrogel design and functionality through photo-processing have stretched the limits of innovation. As both photochemical understanding and engineering technologies continue to develop, more complicated geometries and spatiotemporal manipulations can be realized through photo-exposure, producing multifunctional hydrogels with specific chemical, biological and physical characteristics for the achievement of biomedical goals. This report describes the role that light has recently played in the synthesis and functionalization of biomedical hydrogels and primarily the design of photoresponsive hydrogels via different chemical reactions (photo crosslinking and photo degradation) and conventional light curing processes (micropatterning, stereolithography and two/multiphoton techniques) as well as typical biomedical applications of the hydrogels (cell culture, differentiation and in vivo vascularization) and their promising future.
通过光处理进行生物医学水凝胶设计和功能化的大量机会拓展了创新的边界。随着光化学理解和工程技术的不断发展，通过光照射可以实现更复杂的几何形状和时空操纵，从而制备出具有特定化学、生物学和物理特性的多功能水凝胶，以实现生物医学目标。本报告描述了光最近在生物医学水凝胶的合成和功能化中所起的作用，主要介绍了通过不同化学反应（光交联和光降解）以及传统光固化工艺（微图案化、立体光刻和双光子/多光子技术）设计光响应水凝胶，以及水凝胶的典型生物医学应用（细胞培养、分化和体内血管生成）及其广阔的未来前景。
