Peris Edgar, Porcar Raúl, Macia María, Alcázar Jesús, García-Verdugo Eduardo, Luis Santiago V
Dpt. of Inorganic and Organic Chemistry, Supramolecular and Sustainable Chemistry Group, University Jaume I, Avda Sos Baynat s/n, E-12071-Castellon, Spain.
Discovery Chemistry, Janssen Research and Development, Janssen-Cilag, S.A., C/ Jarama 75A, Toledo, Spain.
Beilstein J Org Chem. 2020 Aug 6;16:1924-1935. doi: 10.3762/bjoc.16.159. eCollection 2020.
The combination of supported ionic liquids and immobilized NHC-Pd-RuPhos led to active and more stable systems for the Negishi reaction under continuous flow conditions than those solely based on NHC-Pd-RuPhos. The fine tuning of the NHC-Pd catalyst and the SILLPs is a key factor for the optimization of the release and catch mechanism leading to a catalytic system easily recoverable and reusable for a large number of catalytic cycles enhancing the long-term catalytic performance.
负载离子液体与固定化NHC-Pd-RuPhos的组合，相较于仅基于NHC-Pd-RuPhos的体系，在连续流动条件下可形成用于Negishi反应的活性更高且更稳定的体系。对NHC-Pd催化剂和SILLPs进行微调，是优化释放和捕获机制的关键因素，该机制可形成一种易于回收和重复使用的催化体系，适用于大量催化循环，从而提高长期催化性能。
