Bryan C L, Jenkinson S G
Division of Pulmonary Diseases/Critical Care Medicine, University of Texas Health Science Center, San Antonio.
Clin Chest Med. 1988 Mar;9(1):141-52.
Ventilating patients with elevated oxygen tensions alters normal respiratory physiology and may damage lung tissue, depending on coexisting host and iatrogenic factors. Pulmonary oxygen toxicity begins at a cellular level when the generation of reduced oxygen intermediates exceeds local defenses. The mainstay of therapy is prevention. Supplemental oxygen should be prescribed at the lowest concentration possible that will still allow adequate tissue oxygenation. Presently, no specific therapeutic interventions are approved for use in humans to treat pulmonary oxygen toxicity. New agents that act as free radical scavengers or reduce free radical formation may prove useful in future clinical trials based on many of the scientific studies summarized in this review.
给氧分压升高的患者通气会改变正常呼吸生理，并且可能损害肺组织，这取决于并存的宿主因素和医源性因素。当低氧中间产物的生成超过局部防御能力时，肺氧中毒始于细胞水平。治疗的主要方法是预防。应给予能维持足够组织氧合的尽可能低浓度的补充氧气。目前，尚无经批准用于人类治疗肺氧中毒的特异性治疗干预措施。基于本综述总结的许多科学研究，作为自由基清除剂或减少自由基形成的新型药物可能在未来临床试验中证明有用。
