Turan Elif, Karaaslan Ozgul
Department of Endocrinology and Metabolic Disease, Medical School of Yozgat Bozok University, Yozgat, Turkey.
Department of Psychiatry, Medical School of Yozgat Bozok University, Yozgat, Turkey.
Oman Med J. 2020 Jul 31;35(4):e161. doi: 10.5001/omj.2020.84. eCollection 2020 Jul.
Selenium and iodine are essential microelements for normal body functions. These two elements play important roles in thyroid metabolism. The potential relationship between thyroid diseases and mental disorders have been demonstrated. We aimed to investigate the relationship between selenium and iodine levels with anxiety and depression in patients with euthyroid nodular goiter (ENG).
In this cross-sectional study, we enrolled 102 consecutive patients with ENG who attended the endocrine outpatient clinic between January 2018 and June 2018. We noted the patient's demographics, thyroid ultrasound imaging, thyroid hormones, and urinary iodine concentration (UIC) results. We also obtained venous blood samples for serum selenium measurement. The same psychiatrist completed the Beck Anxiety Inventory (BAI) and Hamilton Depression Rating Scale (HDRS) for all participants. The study population was dichotomized according to the median values of selenium levels and UIC.
BAI and HDRS scores were significantly higher in the low selenium group than the high selenium group ( 0.032 and 0.042, respectively). BAI scores were significantly higher in the low UIC group than the high UIC group ( 0.007).
Low selenium and UIC levels may contribute to the development of anxiety and depression, independent of thyroid functions, in patients with ENG. In these patients, selenium and iodine replacement may be useful for the prevention of anxiety and depression, especially in deficient regions.
硒和碘是维持人体正常功能所必需的微量元素。这两种元素在甲状腺代谢中发挥着重要作用。甲状腺疾病与精神障碍之间的潜在关系已得到证实。我们旨在研究甲状腺功能正常的结节性甲状腺肿（ENG）患者中硒和碘水平与焦虑和抑郁之间的关系。
在这项横断面研究中，我们纳入了2018年1月至2018年6月期间在内分泌门诊就诊的102例连续性ENG患者。我们记录了患者的人口统计学信息、甲状腺超声成像、甲状腺激素和尿碘浓度（UIC）结果。我们还采集了静脉血样本用于测定血清硒。同一位精神科医生为所有参与者完成了贝克焦虑量表（BAI）和汉密尔顿抑郁评定量表（HDRS）。根据硒水平和UIC的中位数将研究人群分为两组。
低硒组的BAI和HDRS评分显著高于高硒组（分别为0.032和0.042）。低UIC组的BAI评分显著高于高UIC组（0.007）。
低硒和低UIC水平可能导致ENG患者出现焦虑和抑郁，且独立于甲状腺功能。对于这些患者，补充硒和碘可能有助于预防焦虑和抑郁，尤其是在缺乏这些元素的地区。
