Bakhtiari Sedigheh, Yadegari Zahra, Kaviyani Marziyeh, Namazi Zahra, Bakhshi Mahin
Department of Oral Medicine, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Dental Biomaterials, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Scientifica (Cairo). 2020 Jul 28;2020:2950856. doi: 10.1155/2020/2950856. eCollection 2020.
Pemphigus is a chronic inflammatory and autoimmune disease which can cause blisters and mucocutaneous erosions. ABO secretor refers to those who secrete ABO blood group antigens based on their blood type in body fluids such as saliva, sweat, tears, semen, and serum. Previous studies showed that nonsecretor people are more prone to certain autoimmune diseases.
The aim of this study was to determine the ABO secretor status in the saliva of patients with pemphigus vulgaris.
This case-control study was conducted on 35 patients with pemphigus vulgaris and 35 healthy controls. The two groups were matched for age and gender. Pemphigus vulgaris diagnosis was confirmed by histopathology and direct immunofluorescence microscopy. ABO blood grouping was done, and 5 ml of unstimulated saliva was collected to determine secretor status. Secretors were recognized from nonsecretors by the Wiener agglutination inhibition test. Results were extracted by using statistical chi-square and Fisher's exact tests.
16 male and 19 female patients aged 49.43 ± .12.37 years were compared with 16 male and 19 female controls aged 46.43 ± 11.88 years. The most frequent blood group among case and control groups was O (54.3% and 60%, respectively). There was no significant difference in blood groups (=0.73). 90% of the samples were ABO secretors. The patient group included 31 (88.6%) and the control group included 32 (91.4%) ABO secretors; there was no significant difference between the two groups (=1.000).
In this study, we observed that the people with nonsecretor status in comparison with the people with secretor status are not more susceptible to develop pemphigus vulgaris.
天疱疮是一种慢性炎症性自身免疫性疾病，可导致水疱和黏膜皮肤糜烂。ABO分泌型是指那些根据其血型在唾液、汗液、眼泪、精液和血清等体液中分泌ABO血型抗原的人。先前的研究表明，非分泌型人群更容易患某些自身免疫性疾病。
本研究的目的是确定寻常型天疱疮患者唾液中的ABO分泌型状态。
本病例对照研究对35例寻常型天疱疮患者和35例健康对照进行。两组在年龄和性别上相匹配。寻常型天疱疮的诊断通过组织病理学和直接免疫荧光显微镜检查得以证实。进行ABO血型分组，并收集5毫升未刺激的唾液以确定分泌型状态。通过维纳凝集抑制试验从非分泌型中识别出分泌型。使用统计卡方检验和费舍尔精确检验提取结果。
将16名男性和19名女性患者（年龄49.43±12.37岁）与16名男性和19名女性对照（年龄46.43±11.88岁）进行比较。病例组和对照组中最常见的血型是O型（分别为54.3%和60%）。血型方面无显著差异（P=0.73）。90%的样本为ABO分泌型。患者组中有31例（88.6%）ABO分泌型，对照组中有32例（91.4%）ABO分泌型；两组之间无显著差异（P=1.000）。
在本研究中，我们观察到与分泌型状态的人相比，非分泌型状态的人患寻常型天疱疮的易感性并不更高。
