印度北部人群中基因多态性与慢性阻塞性肺疾病风险之间的关联。
Association between gene polymorphism and the risk of chronic obstructive pulmonary disease in the north Indian population.
作者信息
Kirtipal Nikhil, Thakur Hitender, Sobti Ranbir Chander, Janmeja Ashok Kumar
机构信息
Department of Biotechnology, Panjab University, Chandigarh-160014, India.
Assistant Professor, Dept. of Biotechnology, SUSCET, Tangori, Punjab-140306, India.
出版信息
Mol Biol Res Commun. 2020 Jun;9(2):41-43. doi: 10.22099/mbrc.2019.34594.1431.
Interleukin-6 (IL6) is encoded by the gene in human and acts as pro-inflammatory cytokine and an anti-inflammatory cytokine. Recent studies established that substantially contribute in the diagnosed of systemic inflammation for the patients suffering from lung diseases such as chronic obstructive pulmonary disease (COPD). Thereof, this work aimed to investigate the protagonist of (-174 G/C) genotypes as an essential risk factor for COPD in north Indian population. In the study, a total of 200 clinically diagnosed patients with COPD were selected against 200 patients. Statistical analysis reveleaed that there was no significant association between the IL6 -174 G/C genetic polymorphism and the risk of COPD (P>0.05).
白细胞介素-6（IL6）在人类中由该基因编码，起促炎细胞因子和抗炎细胞因子的作用。最近的研究表明，对于患有慢性阻塞性肺疾病（COPD）等肺部疾病的患者，其在全身炎症的诊断中起重要作用。因此，这项工作旨在研究（-174 G/C）基因型作为印度北部人群COPD重要危险因素的作用。在该研究中，共选择了200例临床诊断为COPD的患者与200例对照患者。统计分析表明，IL6 -174 G/C基因多态性与COPD风险之间无显著关联（P>0.05）。
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