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2
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Association between chronic obstructive pulmonary disease and interleukins gene variants: A systematic review and meta-analysis.慢性阻塞性肺疾病与白细胞介素基因变异的相关性：系统评价和荟萃分析。
Cytokine. 2019 May;117:65-71. doi: 10.1016/j.cyto.2019.02.003. Epub 2019 Feb 28.
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[Association of cytokines genes (ILL, IL1RN, TNF, LTA, IL6, IL8, IL0) polymorphic markers with chronic obstructive pulmonary disease].[细胞因子基因（白细胞介素、白细胞介素1受体拮抗剂、肿瘤坏死因子、淋巴毒素α、白细胞介素6、白细胞介素8、白细胞介素10）多态性标记与慢性阻塞性肺疾病的关联]
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Genetic polymorphisms of IL6 gene -174G > C and -597G > A are associated with the risk of COVID-19 severity.IL6 基因的遗传多态性 -174G>C 和 -597G>A 与 COVID-19 严重程度的风险相关。
Int J Immunogenet. 2023 Feb;50(1):5-11. doi: 10.1111/iji.12605. Epub 2022 Nov 2.
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Evaluation of the relationship between IL-6 gene single nucleotide polymorphisms and the severity of COVID-19 in an Iranian population.评价 IL-6 基因单核苷酸多态性与伊朗人群中 COVID-19 严重程度的关系。
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本文引用的文献

1
Insertion/deletion polymorphism of angiotensin-converting enzyme and chronic obstructive pulmonary disease: A case-control study on north Indian population.血管紧张素转换酶插入/缺失多态性与慢性阻塞性肺疾病：一项针对印度北部人群的病例对照研究。
Mol Biol Res Commun. 2019 Dec;8(4):167-170. doi: 10.22099/mbrc.2019.34904.1438.
2
Non-redundant Functions of IL-6 Produced by Macrophages and Dendritic Cells in Allergic Airway Inflammation.巨噬细胞和树突状细胞产生的白细胞介素 6 在过敏性气道炎症中的非冗余功能。
Front Immunol. 2018 Nov 26;9:2718. doi: 10.3389/fimmu.2018.02718. eCollection 2018.
3
The Interplay Between Immune Response and Bacterial Infection in COPD: Focus Upon Non-typeable .COPD 中免疫反应与细菌感染的相互作用：聚焦于不可分型。
Front Immunol. 2018 Nov 5;9:2530. doi: 10.3389/fimmu.2018.02530. eCollection 2018.
4
Chronic obstructive pulmonary disease with mild airflow limitation: current knowledge and proposal for future research - a consensus document from six scientific societies.伴有轻度气流受限的慢性阻塞性肺疾病：当前认知与未来研究建议——六家科学学会的共识文件
Int J Chron Obstruct Pulmon Dis. 2017 Aug 29;12:2593-2610. doi: 10.2147/COPD.S132236. eCollection 2017.
5
Erratum to "Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report: GOLD Executive Summary" [Arch Bronconeumol. 2017;53:128-49].《慢性阻塞性肺疾病诊断、管理和预防全球策略2017报告：GOLD执行摘要》勘误 [《Arch Bronconeumol》。2017年；53:128 - 49] 。
Arch Bronconeumol. 2017 Jul;53(7):411-412. doi: 10.1016/j.arbres.2017.06.001.
6
Inflammatory mechanisms in patients with chronic obstructive pulmonary disease.慢性阻塞性肺疾病患者的炎症机制。
J Allergy Clin Immunol. 2016 Jul;138(1):16-27. doi: 10.1016/j.jaci.2016.05.011. Epub 2016 May 27.
7
Association between -174 G/C polymorphism of interleukin-6 gene and alcoholism.白细胞介素-6基因-174 G/C多态性与酒精中毒之间的关联。
Acta Neuropsychiatr. 2003 Oct;15(5):257-61. doi: 10.1034/j.1601-5215.2003.00040.x.
8
Interleukin-6 as a therapeutic target.白细胞介素 6 作为治疗靶点。
Clin Cancer Res. 2015 Mar 15;21(6):1248-57. doi: 10.1158/1078-0432.CCR-14-2291. Epub 2015 Jan 14.
9
Association of IL-6 gene polymorphisms and COPD in a Spanish population.西班牙人群中白细胞介素-6基因多态性与慢性阻塞性肺疾病的关联
Respir Med. 2008 Dec;102(12):1805-11. doi: 10.1016/j.rmed.2008.06.012. Epub 2008 Aug 9.
10
TNF-alpha-, TNF-beta-, IL-6-, and IL-10-promoter polymorphisms in patients with chronic obstructive pulmonary disease.慢性阻塞性肺疾病患者中肿瘤坏死因子-α、肿瘤坏死因子-β、白细胞介素-6和白细胞介素-10启动子多态性
Tissue Antigens. 2005 Jan;65(1):93-100. doi: 10.1111/j.1399-0039.2005.00343.x.

印度北部人群中基因多态性与慢性阻塞性肺疾病风险之间的关联。

Association between gene polymorphism and the risk of chronic obstructive pulmonary disease in the north Indian population.

作者信息

Kirtipal Nikhil, Thakur Hitender, Sobti Ranbir Chander, Janmeja Ashok Kumar

机构信息

Department of Biotechnology, Panjab University, Chandigarh-160014, India.

Assistant Professor, Dept. of Biotechnology, SUSCET, Tangori, Punjab-140306, India.

出版信息

Mol Biol Res Commun. 2020 Jun;9(2):41-43. doi: 10.22099/mbrc.2019.34594.1431.

DOI:10.22099/mbrc.2019.34594.1431
PMID:32802897
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7382402/
Abstract

Interleukin-6 (IL6) is encoded by the gene in human and acts as pro-inflammatory cytokine and an anti-inflammatory cytokine. Recent studies established that substantially contribute in the diagnosed of systemic inflammation for the patients suffering from lung diseases such as chronic obstructive pulmonary disease (COPD). Thereof, this work aimed to investigate the protagonist of (-174 G/C) genotypes as an essential risk factor for COPD in north Indian population. In the study, a total of 200 clinically diagnosed patients with COPD were selected against 200 patients. Statistical analysis reveleaed that there was no significant association between the IL6 -174 G/C genetic polymorphism and the risk of COPD (P>0.05).

摘要

白细胞介素-6（IL6）在人类中由该基因编码，起促炎细胞因子和抗炎细胞因子的作用。最近的研究表明，对于患有慢性阻塞性肺疾病（COPD）等肺部疾病的患者，其在全身炎症的诊断中起重要作用。因此，这项工作旨在研究（-174 G/C）基因型作为印度北部人群COPD重要危险因素的作用。在该研究中，共选择了200例临床诊断为COPD的患者与200例对照患者。统计分析表明，IL6 -174 G/C基因多态性与COPD风险之间无显著关联（P>0.05）。