Sinclair Alan J, Abdelhafiz Ahmed H
Foundation for Diabetes Research in Older People, Diabetes Frail Ltd.
Kings College, London.
Cardiovasc Endocrinol Metab. 2020 Feb 22;9(3):90-95. doi: 10.1097/XCE.0000000000000193. eCollection 2020 Sep.
Ageing is associated with chronic inflammation and oxidative stress that increase the risk of cardiovascular disease. Frailty and sarcopenia, which are associated with increased visceral obesity and muscle mass loss, are now emerging as new potential risk factors for cardiovascular disease. Increased muscle visceral fat leads to increased secretion of harmful proinflammatory adipokines and reduced muscle mass leads to reduced secretion of the protective myokines creating an abnormal cardiometabolic state increasing the risk of cardiovascular disease. This review: (1) explore traditional and newly emerging cardiometabolic risk factors in older people; (2) investigate methods of prediction and prevention of cardiovascular disease in those with diabetes; and (3) concludes that the development of a subspeciality of Cardiometabolic Medicine should be considered.
衰老与慢性炎症和氧化应激相关，而这会增加心血管疾病的风险。衰弱和肌肉减少症与内脏肥胖增加和肌肉量流失有关，目前正成为心血管疾病新的潜在风险因素。肌肉内脏脂肪增加会导致有害促炎脂肪因子分泌增加，而肌肉量减少会导致保护性肌动蛋白分泌减少，从而造成异常的心脏代谢状态，增加心血管疾病风险。本综述：（1）探讨老年人传统和新出现的心脏代谢风险因素；（2）研究糖尿病患者心血管疾病的预测和预防方法；（3）得出应考虑发展心脏代谢医学亚专业的结论。
