Wang Yibo, Liu Yunlong, Chen Erman, Pan Zhijun
Department of Orthopedics, The Second Affiliated Hospital, Zhejiang University School of Medicine, No. 88, Jiefang Road, Hangzhou, 310009, China.
Cell Tissue Res. 2020 Dec;382(3):457-462. doi: 10.1007/s00441-020-03272-z. Epub 2020 Aug 17.
Mesenchymal stem cells (MSCs) hold enormous potential for the treatment of immune-related conditions and degenerative diseases, owing to their self-renewal and multilineage differentiation capabilities. Nevertheless, cellular senescence significantly impacts the quantity and quality of MSCs, limiting their clinical use. Mitochondria play essential roles in energy production by oxidative phosphorylation and metabolism of energy sources via the tricarboxylic acid cycle. Therefore, mitochondrial dysfunction is a primary cause of senescence in MSCs. Herein, we summarize the current knowledge regarding the mechanisms underlying mitochondrial dysfunction-associated cellular senescence. We also discuss potential methods to prevent or even reverse MSC senescence.
间充质干细胞（MSCs）因其自我更新和多向分化能力，在治疗免疫相关疾病和退行性疾病方面具有巨大潜力。然而，细胞衰老显著影响MSCs的数量和质量，限制了它们的临床应用。线粒体在通过氧化磷酸化产生能量以及通过三羧酸循环进行能源代谢方面发挥着重要作用。因此，线粒体功能障碍是MSCs衰老的主要原因。在此，我们总结了目前关于线粒体功能障碍相关细胞衰老潜在机制的知识。我们还讨论了预防甚至逆转MSCs衰老的潜在方法。
