Hofert J F, Mahowald T A, Mahowald N A, Heidrick M L
Department of Biochemistry, University of Nebraska College of Medicine, Omaha 68105.
Experientia. 1988 Jan 15;44(1):37-8. doi: 10.1007/BF01960236.
To determine if thymic macrophages have insulin receptors, alternate sections of rat thymus were stained with FITC-insulin and examined for nonspecific esterase (ANAE) activity. Cells showing a diffuse ANAE staining pattern also bound FITC-insulin. These cells were concentrated in the cortico-medullary border and increased in number following administration of cortisol. Thymic macrophages may be insulin-dependent and therefore could be malfunctional in diabetes.
为了确定胸腺巨噬细胞是否具有胰岛素受体，将大鼠胸腺的连续切片用异硫氰酸荧光素标记的胰岛素（FITC-胰岛素）进行染色，并检测非特异性酯酶（ANAE）活性。呈现弥漫性ANAE染色模式的细胞也结合了FITC-胰岛素。这些细胞集中在皮质-髓质交界处，在给予皮质醇后数量增加。胸腺巨噬细胞可能依赖胰岛素，因此在糖尿病中可能功能异常。
