Handwerger B S, Fernandes G, Brown D M
Hum Pathol. 1980 Jul;11(4):338-52. doi: 10.1016/s0046-8177(80)80030-x.
The immune and autoimmune aspects of diabetes mellitus are reviewed. Emphasis is given to the clinical association of diabetes with other autoimmune disease; the increased incidence of organ-specific autoimmunity in diabetic patients; the occurrence of humoral and cell-mediated antipancreas (islet) autoimmunity in diabetes; the association of HLA with juvenile-onset, insulin-dependent diabetes mellitus and with certain specific subpopulations of diabetic patients; the possible role of viruses in the etiology of diabetes; and the occurrence of alterations in humoral and cell-mediated immunity, granulocyte function, and the host defense against infectious agents in human diabetics and in animals with experimental diabetes.
本文综述了糖尿病的免疫及自身免疫方面。重点关注糖尿病与其他自身免疫性疾病的临床关联；糖尿病患者器官特异性自身免疫发生率的增加；糖尿病中体液和细胞介导的抗胰腺（胰岛）自身免疫的发生；HLA与青少年发病的胰岛素依赖型糖尿病以及某些特定糖尿病患者亚群的关联；病毒在糖尿病病因学中的可能作用；以及人类糖尿病患者和实验性糖尿病动物体液和细胞介导免疫、粒细胞功能及宿主抗感染防御的改变情况。
