Balasubramanian R, Hofert J F, Heidrick M L
Immunopharmacology. 1985 Oct;10(2):83-8. doi: 10.1016/0162-3109(85)90033-5.
One week following induction of diabetes in rats by alloxan administration, the thymus and spleen showed marked involution and a highly significant depression of in vivo incorporation of [3H]deoxycytidine into the DNA of these tissues. Adrenalectomy of diabetic rats reduced the decline of lymphatic tissue weight, but uptake of [3H]deoxycytidine into thymic and spleen DNA remained suppressed. These results indicate that in alloxan-induced diabetes, the observed depressed lymphatic tissue weight and cellular proliferation are not simply due to the elevated plasma level of corticosteroids, but are either a result of the insulin deficiency per se or due to other metabolic alterations associated with the diabetic condition.
用四氧嘧啶给大鼠注射诱导糖尿病一周后，胸腺和脾脏出现明显萎缩，且[3H]脱氧胞苷在这些组织DNA中的体内掺入量显著降低。对糖尿病大鼠进行肾上腺切除可减轻淋巴组织重量的下降，但[3H]脱氧胞苷在胸腺和脾脏DNA中的摄取仍受到抑制。这些结果表明，在四氧嘧啶诱导的糖尿病中，观察到的淋巴组织重量降低和细胞增殖受抑制并非仅仅是由于血浆皮质类固醇水平升高所致，而是胰岛素缺乏本身的结果，或者是与糖尿病状态相关的其他代谢改变所致。
