Universidade Federal do Rio Grande - RS - FURG, Av. Italia s/n km 08, Rio Grande, Brazil.
J Med Syst. 2020 Aug 17;44(10):173. doi: 10.1007/s10916-020-01622-6.
The circadian rhythm is responsible for the daily variations in metabolism, and circadian rhythm disorders have direct implications for many diseases, such as obesity and mental disorders. The regulation of sleep time is the most common example of the importance of the circadian rhythm for the functioning of the human body. In this sense, this work aims to study a mathematical and computational model based on multiagent simulation that simulates the synchronization and desynchronization of the circadian rhythm in relation to the pain variables. The results from the multiagent simulation of circadian rhythms show that in relation to pain, sleep, especially its biological rhythms, is directly affected by pain. In this way, our mathematical model was able to show that pain causes changes in the circadian rhythm and it can contribute to the medical field analysis.
昼夜节律负责代谢的日常变化，昼夜节律紊乱对许多疾病有直接影响，如肥胖和精神障碍。睡眠时间的调节是昼夜节律对人体功能重要性的最常见例子。从这个意义上说，这项工作旨在研究一个基于多主体模拟的数学和计算模型，该模型模拟与疼痛变量相关的昼夜节律的同步和不同步。多主体模拟昼夜节律的结果表明，就疼痛而言，睡眠，特别是其生物节律，直接受到疼痛的影响。通过这种方式，我们的数学模型表明疼痛会导致昼夜节律的变化，并能为医学领域的分析做出贡献。
