Centre for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway.
Department of Clinical Science, University of Bergen, Bergen, Norway.
J Alzheimers Dis. 2020;77(3):1117-1127. doi: 10.3233/JAD-200441.
Lipids have important structural roles in cell membranes and changes to these membrane lipids may influence β- and γ-secretase activities and thus contribute to Alzheimer's disease (AD) pathology.
To explore baseline plasma lipid profiling in participants with mild cognitive impairment (MCI) with and without AD pathology.
We identified 261 plasma lipids using reversed-phase liquid chromatography/mass spectrometry in cerebrospinal fluid amyloid positive (Aβ+) or negative (Aβ-) participants with MCI as compared to controls. Additionally, we analyzed the potential associations of plasma lipid profiles with performance on neuropsychological tests at baseline and after two years.
Sphingomyelin (SM) concentrations, particularly, SM(d43:2), were lower in MCI Aβ+ individuals compared to controls. Further, SM(d43:2) was also nominally reduced in MCI Aβ+ individuals compared to MCI Aβ-. No plasma lipids were associated with performance on primary neuropsychological tests at baseline or between the two time points after correction for multiple testing.
Reduced plasma concentrations of SM were associated with AD.
脂质在细胞膜中具有重要的结构作用，这些膜脂质的变化可能会影响β-和γ-分泌酶的活性，从而导致阿尔茨海默病（AD）的病理变化。
探索伴有和不伴有 AD 病理的轻度认知障碍（MCI）患者的基线血浆脂质特征。
我们使用反相液相色谱/质谱法在脑脊液淀粉样蛋白阳性（Aβ+）或阴性（Aβ-）的 MCI 患者中鉴定了 261 种血浆脂质，并与对照组进行了比较。此外，我们还分析了基线和两年后血浆脂质特征与神经心理学测试表现之间的潜在关联。
鞘磷脂（SM）浓度，特别是 SM(d43:2)，在 MCI Aβ+患者中低于对照组。此外，与 MCI Aβ-患者相比，MCI Aβ+患者的 SM(d43:2)也明显降低。经过多次测试校正后，没有任何血浆脂质与基线时的主要神经心理学测试表现或两次测试之间的表现相关。
SM 血浆浓度降低与 AD 相关。
