Psychiatry Department, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey.
Child and Adolescent Psychiatry Department, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey.
Nord J Psychiatry. 2021 Feb;75(2):124-129. doi: 10.1080/08039488.2020.1807048. Epub 2020 Aug 17.
The number of studies investigating inflammatory biomarkers in bipolar disorder has increased significantly in recent years. The neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and monocyte to lymphocyte ratio (MLR) are inexpensive and easy to obtain values used to measure the level of inflammation. This study compared the NLR, PLR, and MLR values in the manic and euthymic phases of the same patients.
Patients who met the inclusion criteria and were hospitalized due to bipolar affective disorder manic episodes at the Ondokuz Mayis University Faculty of Medicine inpatient psychiatry clinic between 01.01.2013 and 01.01.2019 were enrolled in the study. One hundred thirteen patients undergoing manic episodes were included. White blood cells, neutrophil, lymphocyte, platelet, and monocyte counts were retrospectively recorded from complete blood count data collected during the hospital stay, and NLR, PLR, and MLR values were calculated from these.
Neutrophil, platelet, and monocyte counts, as well as NLR, PLR, and MLR values were higher in the manic episodes of bipolar disorder compared to the control group. Decreased neutrophil and lymphocyte counts, and decreased NLR, PLR, and MLR were observed in the remission period after-treatment of the manic bipolar disorder episodes. In the euthymic phase of bipolar disorder, however, platelet and monocyte counts and MLR were higher than in the control group.
The study indicates that NLR and PLR may be used as state markers and that MLR may be used as a trait marker in bipolar disorder.
近年来，研究双相情感障碍炎症生物标志物的数量显著增加。中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）和单核细胞与淋巴细胞比值（MLR）是衡量炎症水平的廉价且易于获得的指标。本研究比较了同一患者躁狂和缓解期的 NLR、PLR 和 MLR 值。
本研究纳入了 2013 年 1 月 1 日至 2019 年 1 月 1 日期间，因双相情感障碍躁狂发作而在奥登纽兹马伊斯大学医学院住院精神病学门诊住院的符合纳入标准的患者。共纳入 113 例躁狂发作患者。从住院期间采集的全血细胞计数数据中回顾性记录白细胞、中性粒细胞、淋巴细胞、血小板和单核细胞计数，并由此计算 NLR、PLR 和 MLR 值。
与对照组相比，双相情感障碍躁狂发作时中性粒细胞、血小板和单核细胞计数以及 NLR、PLR 和 MLR 值更高。躁狂双相障碍发作后治疗缓解期，中性粒细胞和淋巴细胞计数下降，NLR、PLR 和 MLR 下降。然而，在双相障碍的缓解期，血小板和单核细胞计数和 MLR 高于对照组。
研究表明，NLR 和 PLR 可用作状态标志物，MLR 可用作双相障碍的特征标志物。
