Ophthalmology Division, Tel Aviv Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; and.
Retina. 2021 Apr 1;41(4):768-773. doi: 10.1097/IAE.0000000000002951.
To evaluate possible changes in anterior scleral thickness and structure and changes in the anterior segment in eyes receiving multiple intravitreal injections using ultrasound biomicroscopy imaging.
Prospective, interventional, nonrandomized, cross-sectional study. Both eyes from 33 patients previously treated at least by 15 intravitreal injections in one eye only for retinal diseases were included. Intravitreal injections were performed by ophthalmologists using an aseptic standardized procedure. Ultrasound biomicroscopy examination was performed in all eyes, and scleral thickness was measured at the pars plana in four quadrants. Anterior chamber depth and ciliary body size were measured. Scleral thickness in the study eye was compared with the fellow eye. Secondary outcome measures were 1) anterior chamber depth; 2) ciliary body size; 3) scleral qualitative changes in the study eye compared with the fellow eye and 4) risk factors for scleral thinning.
There was no statistically significant difference in scleral thickness between the study and fellow eyes when comparing each quadrant between the two eyes (P = 0.86 superotemporal; P = 0.76 superonasal; P = 0.72 inferonasal; P = 0.55 inferotemporal). Scleral thickness was neither related to the number of injections nor to the duration of treatment in the treated eye.
Multiple intravitreal injections do not impact scleral thickness in a clinical practice using different injection sites.
使用超声生物显微镜成像评估接受多次玻璃体内注射的眼睛的前巩膜厚度和结构以及前段的变化。
前瞻性、干预性、非随机、横断面研究。纳入 33 名患者，这些患者的双眼先前仅在一只眼接受了至少 15 次玻璃体内注射治疗视网膜疾病。眼科医生使用无菌标准化程序进行玻璃体内注射。对所有眼睛进行超声生物显微镜检查，并在四个象限的平面上测量巩膜厚度。测量前房深度和睫状体大小。比较研究眼和对侧眼的巩膜厚度。次要结局指标为：1）前房深度；2）睫状体大小；3）研究眼与对侧眼的巩膜定性变化；4）巩膜变薄的危险因素。
当比较双眼的每个象限时，研究眼和对侧眼的巩膜厚度之间没有统计学差异（P = 0.86 上方颞侧；P = 0.76 上方鼻侧；P = 0.72 下方鼻侧；P = 0.55 下方颞侧）。巩膜厚度既与注射次数无关，也与治疗眼的治疗时间无关。
在使用不同注射部位的临床实践中，多次玻璃体内注射不会影响巩膜厚度。
