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Sphingosine 1-phosphate escapes the Catch-22 of sepsis prevention and mitigation therapies.

作者信息

Blaho Victoria A

机构信息

Immunity and Pathogenesis Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, U.S.A..

出版信息

EBioMedicine. 2020 Sep;59:102952. doi: 10.1016/j.ebiom.2020.102952. Epub 2020 Aug 14.

DOI:10.1016/j.ebiom.2020.102952
PMID:32805627
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7426207/
Abstract
摘要

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本文引用的文献

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Druggable Sphingolipid Pathways: Experimental Models and Clinical Opportunities.可成药的神经酰胺代谢途径：实验模型与临床机遇
Adv Exp Med Biol. 2020;1274:101-135. doi: 10.1007/978-3-030-50621-6_6.
2
S1P lyase inhibition protects against sepsis by promoting disease tolerance via the S1P/S1PR3 axis.S1P 裂解酶抑制通过 S1P/S1PR3 轴促进疾病耐受来预防败血症。
EBioMedicine. 2020 Aug;58:102898. doi: 10.1016/j.ebiom.2020.102898. Epub 2020 Jul 22.
3
SARS-CoV-2 and viral sepsis: observations and hypotheses.SARS-CoV-2 与病毒败血症：观察与假说。
Lancet. 2020 May 9;395(10235):1517-1520. doi: 10.1016/S0140-6736(20)30920-X. Epub 2020 Apr 17.
4
Sepsis: Inflammation Is a Necessary Evil.脓毒症：炎症是一把双刃剑。
Front Cell Dev Biol. 2019 Jun 20;7:108. doi: 10.3389/fcell.2019.00108. eCollection 2019.
5
Risk factors for mortality in elderly and very elderly critically ill patients with sepsis: a prospective, observational, multicenter cohort study.老年及高龄重症脓毒症患者死亡的危险因素：一项前瞻性、观察性、多中心队列研究。
Ann Intensive Care. 2019 Feb 4;9(1):26. doi: 10.1186/s13613-019-0495-x.
6
Fifty years of lyase and a moment of truth: sphingosine phosphate lyase from discovery to disease.五十载裂合酶研究，终见分晓：从发现到疾病，探讨神经酰胺磷酸酶。
J Lipid Res. 2019 Mar;60(3):456-463. doi: 10.1194/jlr.S091181. Epub 2019 Jan 11.
7
The global burden of paediatric and neonatal sepsis: a systematic review.全球儿童和新生儿脓毒症负担：系统评价。
Lancet Respir Med. 2018 Mar;6(3):223-230. doi: 10.1016/S2213-2600(18)30063-8.
8
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).《脓毒症及脓毒性休克第三次国际共识定义（脓毒症-3）》
JAMA. 2016 Feb 23;315(8):801-10. doi: 10.1001/jama.2016.0287.
9
Decreased serum concentrations of sphingosine-1-phosphate in sepsis.脓毒症患者血清中1-磷酸鞘氨醇浓度降低。
Crit Care. 2015 Oct 26;19:372. doi: 10.1186/s13054-015-1089-0.
10
Anthracyclines induce DNA damage response-mediated protection against severe sepsis.蒽环类抗生素诱导 DNA 损伤反应介导的严重脓毒症保护作用。
Immunity. 2013 Nov 14;39(5):874-84. doi: 10.1016/j.immuni.2013.08.039. Epub 2013 Oct 31.