Trimble M R
National Hospitals for Nervous Diseases Department of Neurology, Queen Square, London, England.
J Clin Psychiatry. 1988 Apr;49 Suppl:7-12.
The author reviews the use of carbamazepine in the treatment of epilepsy. The so-called psychotropic effects of carbamazepine were first described after the introduction of the drug to clinical practice in the mid-1960s, and since, several investigators have found relationships between carbamazepine and mood variables in seizure disorder patients. Results of investigations at the National Hospitals, London, suggest that carbamazepine influences behavior disorders, anxiety, and depression in patients with epilepsy. Mechanisms of these psychotropic effects are discussed, including the influence of carbamazepine on limbic-kindled seizures and metabolic effects of the drug. Differences between carbamazepine and other anticonvulsants with regard to effects on mood and behavior are presented.
作者回顾了卡马西平在癫痫治疗中的应用。卡马西平的所谓精神otropic作用在20世纪60年代中期该药物引入临床实践后首次被描述，此后，一些研究人员在癫痫发作障碍患者中发现了卡马西平和情绪变量之间的关系。伦敦国家医院的调查结果表明，卡马西平会影响癫痫患者的行为障碍、焦虑和抑郁。文中讨论了这些精神otropic作用的机制，包括卡马西平对边缘叶点燃性癫痫发作的影响以及该药物的代谢作用。还介绍了卡马西平和其他抗惊厥药在对情绪和行为影响方面的差异。
