Deng Xianrong, Zou Zhuo, Zhang Yuhuan, Gao Jiechang, Liang Taotao, Lu Zhisong, Ming Li Chang
Institute for Clean Energy & Advanced Materials, School of Materials & Energy, Southwest University, Chongqing 400715, PR China; College of Materials Science and Engineering, Yangtze Normal University, Fuling, Chongqing, 408100, PR China.
Institute for Clean Energy & Advanced Materials, School of Materials & Energy, Southwest University, Chongqing 400715, PR China.
J Colloid Interface Sci. 2021 Jan 1;581(Pt B):465-474. doi: 10.1016/j.jcis.2020.07.076. Epub 2020 Jul 25.
Nitric oxide (NO) is an important bio-regulatory and signaling molecule associated with various physiological and pathophysiological pathways, but its sensitive real-time detection is still very challenging due to the low concentration, large diffusivity and fast decay in biological samples. Here an antimony tetroxide (SbO) nanoflowers/reduced graphene oxide (rGO) nanocomposite is synthesized via a facile and eco-friendly solvothermal method to merit-combine highly electroactive SbO nanoflowers with large surficial rGO component for a strong synergistic effect on oxidation of NO. Results demonstrate that the SbO/rGO-based sensor has a low detection limit, high sensitivity, excellent selectivity and fast response for NO detection. The real-time detected NO released from living cells showed significant difference between normal and tumor cells. The SbO nanoflowers/rGO nanocomposite sensor holds a great promise for important applications in biomedical research fields and clinical diagnosis.
一氧化氮（NO）是一种与多种生理和病理生理途径相关的重要生物调节和信号分子，但由于生物样品中浓度低、扩散性大且衰减快，其灵敏的实时检测仍然极具挑战性。在此，通过一种简便且环保的溶剂热法合成了四氧化锑（SbO）纳米花/还原氧化石墨烯（rGO）纳米复合材料，将高电活性的SbO纳米花与大表面积的rGO组分进行优势结合，以对NO氧化产生强烈的协同效应。结果表明，基于SbO/rGO的传感器对NO检测具有低检测限、高灵敏度、优异的选择性和快速响应。从活细胞中实时检测到的NO在正常细胞和肿瘤细胞之间显示出显著差异。SbO纳米花/rGO纳米复合传感器在生物医学研究领域和临床诊断的重要应用中具有广阔前景。
