Zhao Xingyu, Chen Minmin, Wang Hualin, Xia Li, Guo Min, Jiang Suwei, Wang Qian, Li Xingjiang, Yang Xuefei
School of Chemistry and Chemical Engineering, Hefei University of Technology, 230009 Hefei, Anhui, PR China.
School of Chemistry and Chemical Engineering, Hefei University of Technology, 230009 Hefei, Anhui, PR China; Anhui Institute of Agro-Products Intensive Processing Technology, 230009, Hefei, Anhui, PR China.
Mater Sci Eng C Mater Biol Appl. 2020 Nov;116:111221. doi: 10.1016/j.msec.2020.111221. Epub 2020 Jun 20.
Synergistic antibacterial strategies have received growing attention due to their significantly enhanced antibacterial activity. Herein, we demonstrated a synergistic antibacterial strategy based on streptomycin sulfate (SS) loaded polyethylene glycol-MoS/reduced graphene oxide (PEG-MoS/rGO) nanoflakes assisted with near-infrared (NIR). The nanoflakes of PEG-MoS/rGO were ultrasonically exfoliated well from the nanoflowers of PEG-MoS/rGO fabricated by hydrothermal method, which was of antibacterial activity against Staphylococcus aureus and Escherichia coli after loading of SS. Under the irradiation of NIR, the antibacterial activity was significantly enhanced by the synergistic effects of physical damage, protein synthesis inhibition, thermal injury and oxidative stress. Moreover, the cytotoxicity of the nanoflakes was very low. The results suggest the great potential of PEG-MoS/rGO-SS as a photothermal antibacterial agent.
由于其显著增强的抗菌活性，协同抗菌策略受到了越来越多的关注。在此，我们展示了一种基于负载硫酸链霉素（SS）的聚乙二醇 - 二硫化钼/还原氧化石墨烯（PEG - MoS₂/rGO）纳米片并辅以近红外（NIR）的协同抗菌策略。PEG - MoS₂/rGO纳米片通过水热法制备的PEG - MoS₂/rGO纳米花超声良好地剥离得到，在负载SS后对金黄色葡萄球菌和大肠杆菌具有抗菌活性。在近红外照射下，通过物理损伤、蛋白质合成抑制、热损伤和氧化应激的协同作用，抗菌活性显著增强。此外，纳米片的细胞毒性非常低。结果表明PEG - MoS₂/rGO - SS作为光热抗菌剂具有巨大潜力。
