Muller G, Von Theobald P, Levy G, Roffe J L, Le Porrier M
Clinique de Gynécologie-Obstétrique, Centre Hospitalier et Universitaire, Caen.
J Gynecol Obstet Biol Reprod (Paris). 1988;17(1):97-102.
Treatment of subdiaphragmatic Hodgkin's disease with combined radio and chemotherapy results in castration of more than 80% women treated, despite oophorepexy. Several types of oophorepexy (lateral and medial transposition), have been described in the literature. None warranted sufficient schelter to avoid frequent alteration of ovarian function and fertility. We suggest a news technique of subcutaneous ovarian grafting which provides full protection against irradiation. To be successful, this technique requires the creation, prior to grafting, of a receptive cavity, two surgical teams working together, and the use of an operative microscope during transplantation. A mature oocyte was collected by puncture of the ovary containing cavity one year after the operation. Two years later, ovarian cycles remain regular, and follicle growth occurs normally each second of third cycle on the transplanted ovary.
