• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

含甲氧基乙基和磷酰胆碱基团的两亲性无规共聚物的合成及其在水中的自缔合行为

Synthesis of Amphiphilic Statistical Copolymers Bearing Methoxyethyl and Phosphorylcholine Groups and Their Self-Association Behavior in Water.

作者信息

Nguyen Thi Lien, Kawata Yuuki, Ishihara Kazuhiko, Yusa Shin-Ichi

机构信息

Department of Applied Chemistry, Graduate School of Engineering, University of Hyogo, 2167 Shosha, Himeji, Hyogo 671-2280, Japan.

Department of Materials Engineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.

出版信息

Polymers (Basel). 2020 Aug 12;12(8):1808. doi: 10.3390/polym12081808.

DOI:10.3390/polym12081808
PMID:32806599
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7464738/
Abstract

Biocompatible amphiphilic statistical copolymers P(MEA/MPC) composed of 2-methoxyethyl acrylate (MEA) and 2-methacryloyloxyethyl phosphorylcholine (MPC) were prepared with three different mol% of the hydrophilic unit MPC ( = 6, 12 and 46 mol%). The monomer reactivity ratios of MEA () and MPC () were 0.53 and 2.21, respectively. The × value of 1.17 demonstrated that statistical copolymerization was successful. P(MEA/MPC) and P(MEA/MPC) copolymers did not undergo aggregation in water, whereas the P(MEA/MPC) copolymer formed micelles in water with a hydrodynamic radius () of 96.9 nm and a critical aggregation concentration, which was determined using pyrene fluorescence, at 0.0082 g/L. The restricted motion of the protons in the hydrophobic MEA units in the micelles' cores provided additional evidence of self-association in P(MEA/MPC).

摘要

由丙烯酸2-甲氧基乙酯（MEA）和2-甲基丙烯酰氧基乙基磷酰胆碱（MPC）组成的具有生物相容性的两亲性无规共聚物P(MEA/MPC)，是采用三种不同摩尔百分比的亲水性单元MPC（分别为6、12和46摩尔%）制备的。MEA（r₁）和MPC（r₂）的单体竞聚率分别为0.53和2.21。1.17的r₁×r₂值表明无规共聚是成功的。P(MEA/MPC)₆和P(MEA/MPC)₁₂共聚物在水中不会发生聚集，而P(MEA/MPC)₄₆共聚物在水中形成了胶束，其流体力学半径（Rh）为96.9 nm，通过芘荧光测定的临界聚集浓度为0.0082 g/L。胶束核心中疏水性MEA单元中质子的受限运动为P(MEA/MPC)₄₆中的自缔合提供了额外证据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef2a/7464738/a7013de960b9/polymers-12-01808-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef2a/7464738/cf8ac7552609/polymers-12-01808-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef2a/7464738/62bf4c7b7089/polymers-12-01808-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef2a/7464738/6bdfe0463ba0/polymers-12-01808-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef2a/7464738/b008f9a5ae98/polymers-12-01808-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef2a/7464738/8aa77b368604/polymers-12-01808-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef2a/7464738/68932e1e7ad0/polymers-12-01808-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef2a/7464738/95188748e5c2/polymers-12-01808-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef2a/7464738/3e3e4779babc/polymers-12-01808-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef2a/7464738/a7013de960b9/polymers-12-01808-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef2a/7464738/cf8ac7552609/polymers-12-01808-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef2a/7464738/62bf4c7b7089/polymers-12-01808-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef2a/7464738/6bdfe0463ba0/polymers-12-01808-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef2a/7464738/b008f9a5ae98/polymers-12-01808-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef2a/7464738/8aa77b368604/polymers-12-01808-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef2a/7464738/68932e1e7ad0/polymers-12-01808-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef2a/7464738/95188748e5c2/polymers-12-01808-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef2a/7464738/3e3e4779babc/polymers-12-01808-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef2a/7464738/a7013de960b9/polymers-12-01808-g009.jpg

相似文献

1
Synthesis of Amphiphilic Statistical Copolymers Bearing Methoxyethyl and Phosphorylcholine Groups and Their Self-Association Behavior in Water.含甲氧基乙基和磷酰胆碱基团的两亲性无规共聚物的合成及其在水中的自缔合行为
Polymers (Basel). 2020 Aug 12;12(8):1808. doi: 10.3390/polym12081808.
2
Self-Association Behavior of Cell Membrane-Inspired Amphiphilic Random Copolymers in Water.细胞膜启发的两亲性无规共聚物在水中的自缔合行为
Polymers (Basel). 2019 Feb 13;11(2):327. doi: 10.3390/polym11020327.
3
Dynamic motion of phosphorylcholine groups at the surface of poly(2-methacryloyloxyethyl phosphorylcholine-random-2,2,2-trifluoroethyl methacrylate).聚（2-甲基丙烯酰氧基乙基磷酰胆碱-无规-甲基丙烯酸2,2,2-三氟乙酯）表面磷酰胆碱基团的动态运动
J Colloid Interface Sci. 2004 Jun 15;274(2):465-71. doi: 10.1016/j.jcis.2004.02.067.
4
Interaction between phospholipids and biocompatible polymers containing a phosphorylcholine moiety.磷脂与含有磷酰胆碱部分的生物相容性聚合物之间的相互作用。
Biomaterials. 1991 Mar;12(2):121-4. doi: 10.1016/0142-9612(91)90189-h.
5
Copolymers of 2-methacryloyloxyethyl phosphorylcholine (MPC) as biomaterials.2-甲基丙烯酰氧乙基磷酰胆碱（MPC）共聚物作为生物材料。
Biomed Mater Eng. 2004;14(4):345-54.
6
RAFT synthesis and stimulus-induced self-assembly in water of copolymers based on the biocompatible monomer 2-(methacryloyloxy)ethyl phosphorylcholine.基于生物相容性单体 2-(甲基丙烯酰氧)乙基磷酸胆碱的嵌段共聚物的 RAFT 合成及水相刺激自组装。
Biomacromolecules. 2009 Apr 13;10(4):950-8. doi: 10.1021/bm8014945.
7
Synthesis of graft copolymers based on poly(2-methoxyethyl acrylate) and investigation of the associated water structure.基于聚（2-甲氧基乙基丙烯酸酯）的接枝共聚物的合成及其相关水结构的研究。
Macromol Rapid Commun. 2012 Feb 27;33(4):319-25. doi: 10.1002/marc.201100698. Epub 2012 Jan 23.
8
Phosphorylcholine-based pH-responsive diblock copolymer micelles as drug delivery vehicles: light scattering, electron microscopy, and fluorescence experiments.基于磷酰胆碱的pH响应性二嵌段共聚物胶束作为药物递送载体：光散射、电子显微镜和荧光实验
Biomacromolecules. 2006 Mar;7(3):817-28. doi: 10.1021/bm0508921.
9
Separated Micelles Formation of pH-Responsive Random and Block Copolymers Containing Phosphorylcholine Groups.含磷酰胆碱基团的pH响应性无规共聚物和嵌段共聚物的胶束形成
Polymers (Basel). 2022 Jan 31;14(3):577. doi: 10.3390/polym14030577.
10
Novel biomimetic polymersomes as polymer therapeutics for drug delivery.新型仿生聚合物囊泡作为用于药物递送的聚合物治疗剂。
J Control Release. 2005 Oct 20;107(3):502-12. doi: 10.1016/j.jconrel.2005.06.013.

引用本文的文献

1
Diblock Copolymers of Methacryloyloxyethyl Phosphorylcholine and Dopamine Methacrylamide: Synthesis and Real-Time Adsorption Dynamics by SEIRAS and RAIRS.甲基丙烯酰氧基乙基磷酰胆碱与多巴胺甲基丙烯酰胺的二嵌段共聚物：通过表面增强红外吸收光谱（SEIRAS）和反射吸收红外光谱（RAIRS）进行的合成及实时吸附动力学研究
Langmuir. 2024 Mar 19;40(11):5945-5958. doi: 10.1021/acs.langmuir.3c03925. Epub 2024 Mar 8.
2
The Nanostructured Self-Assembly and Thermoresponsiveness in Water of Amphiphilic Copolymers Carrying Oligoethylene Glycol and Polysiloxane Side Chains.带有聚乙二醇和聚硅氧烷侧链的两亲性共聚物在水中的纳米结构自组装及热响应性
Pharmaceutics. 2023 Jun 10;15(6):1703. doi: 10.3390/pharmaceutics15061703.
3

本文引用的文献

1
Interfacial Structures and Fibrinogen Adsorption at Blood-Compatible Polymer/Water Interfaces.血液相容性聚合物/水界面的界面结构与纤维蛋白原吸附
ACS Biomater Sci Eng. 2016 Dec 12;2(12):2122-2126. doi: 10.1021/acsbiomaterials.6b00415. Epub 2016 Oct 27.
2
Antithrombogenic Properties of Amphiphilic Block Copolymer Coatings: Evaluation of Hemocompatibility Using Whole Blood.两亲性嵌段共聚物涂层的抗血栓形成特性：使用全血评估血液相容性
ACS Biomater Sci Eng. 2015 Jun 8;1(6):352-362. doi: 10.1021/acsbiomaterials.5b00079. Epub 2015 May 22.
3
Revolutionary advances in 2-methacryloyloxyethyl phosphorylcholine polymers as biomaterials.
Cellular Internalization and Exiting Behavior of Zwitterionic 4-Armed Star-Shaped Polymers.
两性离子 4 臂星形聚合物的细胞内化和出胞行为。
Molecules. 2023 Jun 1;28(11):4479. doi: 10.3390/molecules28114479.
作为生物材料的 2-（甲基丙烯酰氧）乙基磷酸胆碱聚合物的革命性进展。
J Biomed Mater Res A. 2019 May;107(5):933-943. doi: 10.1002/jbm.a.36635. Epub 2019 Feb 13.
4
Poly(ω-methoxyalkyl acrylate)s: Nonthrombogenic Polymer Family with Tunable Protein Adsorption.聚（ω-甲氧基烷基丙烯酸酯）：具有可调节蛋白质吸附性能的非血栓性聚合物家族。
Biomacromolecules. 2017 Dec 11;18(12):4214-4223. doi: 10.1021/acs.biomac.7b01247. Epub 2017 Nov 28.
5
Cell membrane-inspired phospholipid polymers for developing medical devices with excellent biointerfaces.受细胞膜启发的磷脂聚合物，用于开发具有优异生物界面的医疗设备。
Sci Technol Adv Mater. 2012 Oct 18;13(6):064101. doi: 10.1088/1468-6996/13/6/064101. eCollection 2012 Dec.
6
Reduced Blood Cell Adhesion on Polypropylene Substrates through a Simple Surface Zwitterionization.通过简单的表面两性离子化降低聚丙稀基底上的红细胞黏附。
Langmuir. 2017 Jan 17;33(2):611-621. doi: 10.1021/acs.langmuir.6b03295. Epub 2016 Nov 17.
7
Blood-Compatible Polymer for Hepatocyte Culture with High Hepatocyte-Specific Functions toward Bioartificial Liver Development.用于肝细胞培养的血液相容性聚合物，对生物人工肝的发展具有高度肝细胞特异性功能。
ACS Appl Mater Interfaces. 2015 Aug 19;7(32):18096-103. doi: 10.1021/acsami.5b05210. Epub 2015 Aug 10.
8
Applications of polymer micelles for imaging and drug delivery.聚合物胶束在成像和药物递送中的应用。
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2015 Sep-Oct;7(5):691-707. doi: 10.1002/wnan.1332. Epub 2015 Feb 13.
9
Self-assembly of random copolymers.无规共聚物的自组装
Chem Commun (Camb). 2014 Nov 14;50(88):13417-32. doi: 10.1039/c4cc03688c.
10
In vivo targeted deep-tissue photodynamic therapy based on near-infrared light triggered upconversion nanoconstruct.基于近红外光触发上转换纳米构建体的体内靶向深层组织光动力疗法。
ACS Nano. 2013 Jan 22;7(1):676-88. doi: 10.1021/nn304872n. Epub 2012 Dec 24.