受细胞膜启发的磷脂聚合物，用于开发具有优异生物界面的医疗设备。
Cell membrane-inspired phospholipid polymers for developing medical devices with excellent biointerfaces.
作者信息
Iwasaki Yasuhiko, Ishihara Kazuhiko
机构信息
Department of Chemistry and Materials Engineering, Faculty of Chemistry, Materials and Bioengineering, Kansai University, 3-3-35 Yamate-cho, Suita-shi, Osaka, 564-8680, Japan.
Department of Materials Engineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.
出版信息
Sci Technol Adv Mater. 2012 Oct 18;13(6):064101. doi: 10.1088/1468-6996/13/6/064101. eCollection 2012 Dec.
This review article describes fundamental aspects of cell membrane-inspired phospholipid polymers and their usefulness in the development of medical devices. Since the early 1990s, polymers composed of 2-methacryloyloxyethyl phosphorylcholine (MPC) units have been considered in the preparation of biomaterials. MPC polymers can provide an artificial cell membrane structure at the surface and serve as excellent biointerfaces between artificial and biological systems. They have also been applied in the surface modification of some medical devices including long-term implantable artificial organs. An MPC polymer biointerface can suppress unfavorable biological reactions such as protein adsorption and cell adhesion - in other words, specific biomolecules immobilized on an MPC polymer surface retain their original functions. MPC polymers are also being increasingly used for creating biointerfaces with artificial cell membrane structures.
这篇综述文章描述了受细胞膜启发的磷脂聚合物的基本方面及其在医疗器械开发中的用途。自20世纪90年代初以来，由2-甲基丙烯酰氧基乙基磷酰胆碱（MPC）单元组成的聚合物已被用于生物材料的制备。MPC聚合物可以在表面提供人工细胞膜结构，并作为人工系统与生物系统之间出色的生物界面。它们还被应用于一些医疗器械的表面改性，包括长期可植入的人工器官。MPC聚合物生物界面可以抑制诸如蛋白质吸附和细胞粘附等不利的生物反应——换句话说，固定在MPC聚合物表面的特定生物分子保留其原始功能。MPC聚合物也越来越多地用于创建具有人工细胞膜结构的生物界面。
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