Faculty of Medicine, University of Padjadjaran, Bandung, Indonesia.
Department of Clinical Pathology, Faculty of Medicine, University of Padjadjaran, Hasan Sadikin Hospital, Bandung, Indonesia.
Lupus. 2020 Oct;29(12):1566-1570. doi: 10.1177/0961203320950822. Epub 2020 Aug 17.
We aimed to measure sensitivity, specificity, and to determine the cut-off value (COV) ratio of neutrophil-to-lymphocyte (NLR) in patients with active systemic lupus erythematosus (SLE).
A cross sectional study was conducted using the retrospective data from Hasan Sadikin Lupus Registry (HSLR). The inclusion criteria were SLE patients aged 18 years or older who had documented data of neutrophil, lymphocyte, and SLE disease activity index (SLEDAI). Patients with infections, malignancies, and other inflammatory diseases recorded in registry were excluded. SLEDAI with a score of ≤ 4 is considered inactive and score of > 4 is considered active. The neutrophil-to-lymphocyte ratio was calculated by dividing the absolute number of neutrophils by the absoulte number of lymphocytes. Receiver Operating Characteristic (ROC) curve was used to analyze and determine optimal COV of NLR.
The total sample in this study were 112 subjects with a dominant of female (95.54%) and the mean age of 34.45 ± 9.40 years. The median of SLEDAI was 4.5 with a range from 0 to 16, while the median of NLR was 2.68 with a range of 0.59 to 19.02. The ROC analysis showed the optimal cut-off in this study was 2.94 with sensitivity and specificity as high as 60.71% and 76.79%, respectively.
Neutrophil-to-lymphocyte ratio with cut off value of 2.94 can be used to determine active disease of systemic lupus eythematousus.
本研究旨在测量中性粒细胞与淋巴细胞比值（NLR）在活动期系统性红斑狼疮（SLE）患者中的敏感性、特异性，并确定其临界值（COV）。
采用回顾性横断面研究，使用哈桑萨迪金狼疮登记处（HSLR）的回顾性数据。纳入标准为年龄≥18 岁且有中性粒细胞、淋巴细胞和系统性红斑狼疮疾病活动指数（SLEDAI）记录的 SLE 患者。排除登记处记录的感染、恶性肿瘤和其他炎症性疾病的患者。SLEDAI 评分≤4 为疾病不活动，评分>4 为疾病活动。通过将中性粒细胞绝对值除以淋巴细胞绝对值计算 NLR。使用受试者工作特征（ROC）曲线分析和确定 NLR 的最佳 COV。
本研究的总样本量为 112 例患者，其中女性占主导（95.54%），平均年龄为 34.45±9.40 岁。SLEDAI 的中位数为 4.5，范围为 0 至 16，而 NLR 的中位数为 2.68，范围为 0.59 至 19.02。ROC 分析显示，本研究的最佳截断值为 2.94，敏感性和特异性分别高达 60.71%和 76.79%。
NLR 的截断值为 2.94 可用于判断系统性红斑狼疮的疾病活动度。
