中性粒细胞与淋巴细胞计数比值作为系统性红斑狼疮炎症标志物的作用。
The role of neutrophyl lymphocyte count ratio as an inflammatory marker in systemic lupus erythematosus.
作者信息
Oehadian Amaylia, Suryadinata Hendarsyah, Dewi Sumartini, Pramudyo Riardi, Alisjahbana Bachti
机构信息
Department of Internal Medicine, Padjadjaran University - Hasan Sadikin Hospital, Bandung, Indonesia.
出版信息
Acta Med Indones. 2013 Jul;45(3):170-4.
AIM
to evaluate neutrophyl lymphocyte count ratio (NLCR) as an inflammatory marker in systemic lupus erythematosus (SLE).
METHODS
this was a cross sectional study involving 21 SLE patients with mild and moderate disease activity according to Mex SLEDAI score and 30 normal subjects. White blood cells counts were examined with Sysmex XE-5000. The absolute neutrophyl count and absolute lymphocyte count were tabulated and compared between SLE and normal subjects using unpaired t-test. The comparison of NLCR between SLE and normal subject was calculated using Mann-Whitney test. This study was conducted in the Department of Internal Medicine Hasan Sadikin Hospital from November 2011 until January 2012.
RESULTS
there was no significant difference in absolute neutrophyl count between SLE and normal subjects (4158+1517 vs 4031+1218 /mm3, p=0.74). The absolute lymphocyte count was significantly lower in SLE than normal subjects (1721+600 vs 2397+587/mm3, p=0.000). NLCR was significantly higher in SLE than normal subjects (2.52 (1.01-10.92) vs 1.65 (0.77-4.59), p=0.007). There was no significant difference in NLCR between SLE with mild and moderate activity (2.59 (1.01-10.92) vs 2.01 (1.38-3.98), p= 0.412). Based on ROC curve, with AUC 0.727, cut off NLCR value >1.93 had 70% sensitivity and 67% specificity in differentiating between SLE and normal subjects.
CONCLUSION
NLCR could be used as simple inflammatory parameter in SLE.
目的
评估中性粒细胞与淋巴细胞计数比值（NLCR）作为系统性红斑狼疮（SLE）炎症标志物的价值。
方法
本研究为横断面研究，纳入21例根据墨西哥SLE疾病活动指数（Mex SLEDAI）评分判定为轻、中度疾病活动的SLE患者及30名正常对照者。采用Sysmex XE - 5000检测白细胞计数。将SLE患者与正常对照者的中性粒细胞绝对值和淋巴细胞绝对值列表，并采用非配对t检验进行比较。采用Mann - Whitney检验计算SLE患者与正常对照者之间NLCR的差异。本研究于2011年11月至2012年1月在哈山·萨迪金医院内科进行。结果：SLE患者与正常对照者的中性粒细胞绝对值无显著差异（4158±1517 vs 4031±1218/mm³，p = 0.74）。SLE患者的淋巴细胞绝对值显著低于正常对照者（1721±600 vs 2397±587/mm³，p = 0.000）。SLE患者的NLCR显著高于正常对照者（2.52（1.01 - 10.92）vs 1.65（0.77 - 4.59），p = 0.007）。轻度和中度活动的SLE患者之间NLCR无显著差异（2.59（1.01 - 10.92）vs 2.01（1.38 - 3.98），p = 0.412）。基于ROC曲线，曲线下面积（AUC）为0.727，NLCR值>1.93在区分SLE患者与正常对照者时，敏感度为70%，特异度为67%。结论：NLCR可作为SLE的一种简单炎症参数。
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