Department of Anesthesiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, 3 Qingchun East Road, Zhejiang, 310016, Hangzhou, China.
J Headache Pain. 2020 Aug 17;21(1):103. doi: 10.1186/s10194-020-01170-x.
Neuropathic pain (NP) is a sustained and nonreversible condition characterized by long-term devastating physical and psychological damage. Therefore, it is urgent to identify an effective treatment for NP. Unfortunately, the precise pathogenesis of NP has not been elucidated. Currently, the microbiota-gut-brain axis has drawn increasing attention, and the emerging role of gut microbiota is investigated in numerous diseases including NP. Gut microbiota is considered as a pivotal regulator in immune, neural, endocrine, and metabolic signaling pathways, which participates in forming a complex network to affect the development of NP directly or indirectly. In this review, we conclude the current understanding of preclinical and clinical findings regarding the role of gut microbiota in NP and provide a novel therapeutic method for pain relief by medication and dietary interventions.
神经病理性疼痛（NP）是一种持续且不可逆转的病症，其特征是长期存在破坏性的身体和心理伤害。因此，迫切需要找到一种有效的 NP 治疗方法。不幸的是，NP 的精确发病机制尚未阐明。目前，菌群-肠-脑轴受到越来越多的关注，肠道菌群在包括 NP 在内的许多疾病中的新兴作用正在被研究。肠道菌群被认为是免疫、神经、内分泌和代谢信号通路的关键调节因子，它参与形成一个复杂的网络，直接或间接地影响 NP 的发展。在这篇综述中，我们总结了目前关于肠道菌群在 NP 中的作用的临床前和临床研究结果，并提供了一种通过药物和饮食干预缓解疼痛的新的治疗方法。
