Faculty of Dentistry, Department of Clinical and Social Dentistry, Federal University of Paraíba, Campus I, João Pessoa, PB, 58051-970, Brazil.
BMC Oral Health. 2020 Aug 17;20(1):223. doi: 10.1186/s12903-020-01212-5.
Fungal infections associated with the use of dentures, like denture stomatitis, are difficult to prevent and treat. This in situ study aimed to investigate the efficacy of cinnamaldehyde for the disinfection of complete removable dentures, and the effect on the physical and mechanical properties (Vickers microhardness, color, and surface roughness) of the acrylic resin.
Acrylic resin disks were inserted into the dentures of a probabilistic sample of 33 complete denture users, that used cinnamaldehyde (27 μg/mL) and 0.5% sodium hypochlorite solutions in a 20 min/7-days protocol of dentures immersion in each solution, with a wash-out period of 7 days, to constitute a crossover-study. The disks were analyzed before and after the immersion, for the presence of microorganisms (CFU/mL) and by scanning electron microscope (SEM). Also, the surface roughness (Ra) and Vickers microhardness were measured, and color parameters were analyzed using the National Bureau of Standards (NBS) method. Data was analyzed by Wilcoxon and Friedman (microbiological evaluation), paired t-test (color and roughness) and independent t-test (Vickers hardness) (α = 0.05).
A significant reduction (P < 0.05) in the number of microorganisms was observed for each species (total microorganisms, Streptococcus mutans, and Candida spp.), with no significant differences (P > 0.05) between hypochlorite and cinnamaldehyde. There was an increase in the roughness and a decrease in the hardness of the test specimens, with no difference between the two disinfectant substances (P > 0.05). Both hypochlorite and cinnamaldehyde also caused changes in color, considered as "perceptible" by the NBS classification, but with no significant difference between disinfectant substances (P < 0.05), and under the clinically acceptable limit (ΔE ≤ 3.7).
The 27 μg/mL cinnamaldehyde solution was effective against all evaluated microorganisms and caused minor alterations in hardness, surface roughness, and color parameters, with no clinical relevance.
与义齿相关的真菌感染，如义齿性口炎，难以预防和治疗。本原位研究旨在探讨肉桂醛对全可摘义齿消毒的效果，以及对丙烯酸树脂物理和机械性能（维氏显微硬度、颜色和表面粗糙度）的影响。
将丙烯酸树脂圆盘插入 33 名全口义齿使用者的义齿中，使用肉桂醛（27μg/mL）和 0.5%次氯酸钠溶液，按照每 20 分钟/7 天的方案将义齿浸泡在每种溶液中，洗脱期为 7 天，构成交叉研究。在浸泡前后对圆盘进行微生物（CFU/mL）分析，并通过扫描电子显微镜（SEM）观察。还测量了表面粗糙度（Ra）和维氏显微硬度，并使用国家标准局（NBS）方法分析了颜色参数。数据采用 Wilcoxon 和 Friedman（微生物评估）、配对 t 检验（颜色和粗糙度）和独立 t 检验（维氏硬度）（α=0.05）进行分析。
每种微生物（总微生物、变形链球菌和念珠菌属）的数量均显著减少（P<0.05），次氯酸钠和肉桂醛之间无显著差异（P>0.05）。测试样本的粗糙度增加，硬度降低，但两种消毒剂之间无差异（P>0.05）。次氯酸钠和肉桂醛也导致颜色发生变化，根据 NBS 分类为“可察觉”，但消毒剂之间无显著差异（P<0.05），且在临床可接受范围内（ΔE≤3.7）。
27μg/mL 的肉桂醛溶液对所有评估的微生物有效，对硬度、表面粗糙度和颜色参数仅产生微小变化，无临床意义。
