全面分析黏蛋白在肺癌中的作用机制及治疗意义。

Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.

J Exp Clin Cancer Res. 2020 Aug 17;39(1):162. doi: 10.1186/s13046-020-01662-3.

Aberrant expression of mucin proteins has played a complex and essential role in cancer development and metastasis. Members of the mucin family have been intimately implicated in lung cancer progression, metastasis, survival and chemo-resistance. During the progression of lung cancer, mucin proteins have involved all of the procession of lung cancer, which is interacted with many receptor tyrosine kinases signal pathways and mediated cell signals for tumor cell growth and survival. Mucins thus have been considerable as the indicator of negative prognosis and desirable therapeutic targets of lung cancers. In this review, we comprehensively analyzed the role of each member of the mucin family in lung cancer by combining open-accessed database analysis and assembling cutting-edge information about these molecules.

黏蛋白蛋白的异常表达在癌症的发生和转移中起着复杂而重要的作用。黏蛋白家族的成员与肺癌的进展、转移、存活和化疗耐药密切相关。在肺癌的发展过程中，黏蛋白蛋白参与了肺癌的整个过程，与许多受体酪氨酸激酶信号通路相互作用，并介导肿瘤细胞生长和存活的细胞信号。因此，黏蛋白被认为是肺癌预后不良的指标和有希望的治疗靶点。在这篇综述中，我们通过结合公开数据库分析和收集有关这些分子的最新信息，全面分析了黏蛋白家族的每个成员在肺癌中的作用。