Dutta Dipankar, Foy Chris, Ramadurai Gopinath, Obaid Mudhar, Bruno Askiel
Stroke Service, Gloucestershire Royal Hospital, Great Western Road, Gloucester GL1 3NN, UK.
Gloucestershire Research Support Service, Gloucestershire Royal Hospital, UK.
J Stroke Cerebrovasc Dis. 2020 Sep;29(9):105024. doi: 10.1016/j.jstrokecerebrovasdis.2020.105024. Epub 2020 Jun 20.
To facilitate modified Rankin scale (mRS) assessments, we developed and tested a smartphone/web application of the simplified mRS questionnaire (e-smRSq). The e-smRSq guides raters towards a final score according to the smRSq algorithm, and offers hints for scoring based on the conventional mRS concepts.
Initially, three experienced mRS certified raters prepared 30 vignettes of unstructured stroke patient interviews, and determined consensus reference scores. Using the e-smRSq, 16 raters of varied professional backgrounds without mRS training scored the mRS for 24 randomly selected vignettes. Subsequently, 5 certified and 5 uncertified raters using the e-smRSq scored 23 mRS certification vignettes developed and used in the Strategies to Innovate Emergency Care Clinical Trials Network-Neurological Emergencies Treatment Trials (SIREN-NETT). Cohen's and Fleiss's kappa (κ), weighted kappa (κw), and intra-class correlation (ICC) compared rater scores with reference scores and assessed interrater reliability.
For the 16 initial raters using the e-smRSq with 24 vignettes, the κ (Fleiss) was 0.62 and ICC 0.87 (CI 0.80-0.93). Comparing raters' scores with reference scores, Cohen's κ was 0.68 and κw 0.90. For the 10 subsequent raters using the e-smRSq on SIREN-NETT vignettes, κ (Fleiss) was 0.8 and ICC 0.95 (CI 0.91-0.97). Comparing all 10 raters scores with SIREN-NETT reference scores, Cohen's κ was 0.88 and κw 0.97. There was no significant difference between certified and uncertified raters.
The e-smRSq appears to have good reproducibility and validity metrics among both certified and non-certified mRS raters, possibly owing to its simplicity. Further testing in stroke patients in warranted.
为便于改良Rankin量表(mRS)评估,我们开发并测试了简化mRS问卷的智能手机/网络应用程序(电子简化mRS问卷,e-smRSq)。e-smRSq根据简化mRS问卷算法引导评估者得出最终分数,并根据传统mRS概念提供评分提示。
最初,三名经验丰富的mRS认证评估者编写了30份非结构化中风患者访谈的案例,并确定了一致的参考分数。16名不同专业背景且未接受mRS培训的评估者使用e-smRSq对24个随机选择的案例进行mRS评分。随后,5名认证评估者和5名未认证评估者使用e-smRSq对在创新急诊护理临床试验网络-神经急症治疗试验(SIREN-NETT)中开发和使用的23个mRS认证案例进行评分。采用Cohen's和Fleiss's卡方(κ)、加权卡方(κw)和组内相关系数(ICC)将评估者分数与参考分数进行比较,并评估评估者间的可靠性。
对于使用e-smRSq对24个案例进行评分的16名初始评估者,κ(Fleiss)为0.62,ICC为0.87(95%CI 0.80-0.93)。将评估者分数与参考分数进行比较,Cohen's κ为0.68,κw为0.90。对于随后在SIREN-NETT案例中使用e-smRSq的10名评估者,κ(Fleiss)为0.8,ICC为0.95(95%CI 0.91-0.97)。将所有10名评估者的分数与SIREN-NETT参考分数进行比较,Cohen's κ为0.88,κw为0.97。认证评估者和未认证评估者之间无显著差异。
e-smRSq在认证和未认证的mRS评估者中似乎都具有良好的可重复性和效度指标,这可能归因于其简单性。有必要在中风患者中进行进一步测试。