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口服植物百里香酚可改善应激引起的 IBS 症状。

Oral Phyto-thymol ameliorates the stress induced IBS symptoms.

机构信息

Department of Pharmaceutical Science and Chinese Traditional Medicine, Southwest University, Beibei, Chongqing, 400715, China.

Research Unit in Bioinformatics (RUBi), Department of Biochemistry and Microbiology, Rhodes University, P.O. Box 94, Grahamstown, 6140, South Africa.

出版信息

Sci Rep. 2020 Aug 17;10(1):13900. doi: 10.1038/s41598-020-70420-4.

DOI:10.1038/s41598-020-70420-4
PMID:32807797
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7431530/
Abstract

Physical stressors play a crucial role in the progression of irritable bowel syndrome (IBS). Here we report a heterogeneous physical stress induced IBS rat model which shows depression and subsequent modulation of IBS by oral treatment of thymol. Oral administration of Thymol reduces the stress induced IBS significantly altering the stress induced gastrointestinal hypermotility, prolonged the whole gut transit time, and increased abdominal withdrawal reflex suggesting gastrointestinal hypermotility and visceral discomfort caused the onset of depression. Immunohistochemical analysis in small intestine and colon of rats shows the decreased 5-HTR expression level while thymol treatment normalized the 5-HTR expression in the stressed rats. Molecular docking studies showed that thymol competes with endogenous serotonin and an antagonist, Tropisetron and all have similar binding energies to 5-HTR. Molecular dynamics simulations revealed that thymol and tropisetron might have similar effects on 5-HTR. Our study suggest that thymol improves IBS symptoms through 5-HTR, could be useful for the treatment of IBS.

摘要

躯体应激在肠易激综合征（IBS）的进展中起着至关重要的作用。在这里，我们报告了一种异质的躯体应激诱导的 IBS 大鼠模型，该模型表现出抑郁，随后通过口服百里香酚进行治疗，可调节 IBS。口服百里香酚可显著减轻应激诱导的 IBS，改变应激诱导的胃肠道过度运动，延长整个肠道通过时间，并增加腹部退缩反射，提示胃肠道过度运动和内脏不适导致抑郁发作。对大鼠小肠和结肠的免疫组织化学分析显示，5-HTR 表达水平降低，而百里香酚治疗可使应激大鼠的 5-HTR 表达正常化。分子对接研究表明，百里香酚与内源性 5-羟色胺竞争，而曲匹司特是一种拮抗剂，它们与 5-HTR 的结合能相似。分子动力学模拟表明，百里香酚和曲匹司特可能对 5-HTR 有相似的作用。我们的研究表明，百里香酚通过 5-HTR 改善 IBS 症状，可能对 IBS 的治疗有用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a5f/7431530/8925bd18fca6/41598_2020_70420_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a5f/7431530/41ea9b7a5794/41598_2020_70420_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a5f/7431530/701be221fd21/41598_2020_70420_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a5f/7431530/b7981361d288/41598_2020_70420_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a5f/7431530/4507d3880e8b/41598_2020_70420_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a5f/7431530/2aae53a2efdd/41598_2020_70420_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a5f/7431530/e23d7c2a2127/41598_2020_70420_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a5f/7431530/8925bd18fca6/41598_2020_70420_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a5f/7431530/41ea9b7a5794/41598_2020_70420_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a5f/7431530/701be221fd21/41598_2020_70420_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a5f/7431530/b7981361d288/41598_2020_70420_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a5f/7431530/4507d3880e8b/41598_2020_70420_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a5f/7431530/2aae53a2efdd/41598_2020_70420_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a5f/7431530/e23d7c2a2127/41598_2020_70420_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a5f/7431530/8925bd18fca6/41598_2020_70420_Fig7_HTML.jpg

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引用本文的文献

[1]
Thymol promotes cell proliferation and protects against LPS-induced intestinal inflammation via activation of the EGFR/PI3K pathway.

Food Sci Biotechnol. 2025-2-24

[2]
The Mechanism of Relieving Diarrheal Irritable Bowel Syndrome Using Polyphenols from L. Based on a Network Pharmacology Analysis and 16S rRNA Sequencing.

Foods. 2024-11-29

[3]
Neuroprotective Effects of Thymol and p-Cymene in Immobilized Male rats through Alterations in Molecular, Biochemical, Histological, and Behavioral Parameters.

Neurochem Res. 2024-11-14

[4]
Anti-inflammatory effects of thymol: an emphasis on the molecular interactions through approach and molecular dynamic simulations.

Front Chem. 2024-6-25

[5]
The effects of curcumin and sertraline on stress-induced changes in the stomach tissues of rats.

Naunyn Schmiedebergs Arch Pharmacol. 2023-9

[6]
Plant Essential Oils as Healthy Functional Ingredients of Nutraceuticals and Diet Supplements: A Review.

Molecules. 2023-1-16

[7]
The effects of on rat colonic hypermotility induced by repeated water avoidance stress and the potential mechanism.

PeerJ. 2022

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