Substitute Military Service, Lo-Sheng Sanatorium and Hospital, Ministry of Health and Welfare, New Taipei City, Taiwan.
Center for Evidence-Based Health Care and Shared Decision Making Resource Center, Department of Medical Research, Taipei Medical University Shuang Ho Hospital, New Taipei City, Taiwan.
Eye (Lond). 2021 Jun;35(6):1629-1636. doi: 10.1038/s41433-020-01132-2. Epub 2020 Aug 17.
Two types of intraocular lenses (IOLs), namely ultraviolet-filtering IOL (UVF-IOL) and blue-light-filtering IOL (BF-IOL), are used to replace the aging lens in cataract patients. This provides a clinical scenario to investigate the BF and UVF effects on circadian rhythm. We revisited this topic and conducted an updated meta-analysis investigating the effects of UVF-IOL and BF-IOL on sleep quality.
A literature search was conducted using the PubMed, Embase, and Cochrane Library databases, and finally, four randomized controlled trials, one nonrandomized controlled study, and two cohort studies were included in this meta-analysis.
The fixed-effect model revealed a significantly larger sleep quality improvement in the UVF-IOL group than in the BF-IOL group (standard mean difference [SMD] = 0.10, 95% confidence interval [CI]: 0.00-0.21) at 3-8 weeks but not 7-12 months after IOL implantation (SMD = 0.03, 95% CI: -0.08 to 0.13). The random effects model revealed no difference between groups at 3-8 weeks (SMD = 0.16, 95% CI: -0.07 to 0.39) and 7-12 months (SMD = 0.03, 95% CI: -0.08 to 0.13) after IOL implantation.
Our study found some weak evidence supporting that UVF-IOL implantation demonstrated a greater improvement in subjective sleep quality than the BF-IOL implantation only in a shorter period but not in a longer period. More trials should be conducted before further recommendations. Nevertheless, our study provides some insights into the effects of short wavelength electromagnetic radiation on the circadian rhythm. PROSPERO registration number: CRD42019128832.
两种类型的人工晶状体（IOL），即紫外线过滤型人工晶状体（UVF-IOL）和蓝光过滤型人工晶状体（BF-IOL），用于替换白内障患者老化的晶状体。这为研究 BF 和 UVF 对昼夜节律的影响提供了临床场景。我们重新研究了这个课题，并进行了一项更新的荟萃分析，研究了 UVF-IOL 和 BF-IOL 对睡眠质量的影响。
使用 PubMed、Embase 和 Cochrane 图书馆数据库进行文献检索，最终纳入了四项随机对照试验、一项非随机对照研究和两项队列研究进行荟萃分析。
固定效应模型显示，在 IOL 植入后 3-8 周时，UVF-IOL 组的睡眠质量改善显著大于 BF-IOL 组（标准化均数差 [SMD] = 0.10，95%置信区间 [CI]：0.00-0.21），但在 IOL 植入后 7-12 个月时无差异（SMD = 0.03，95% CI：-0.08 至 0.13）。随机效应模型显示，在 IOL 植入后 3-8 周（SMD = 0.16，95% CI：-0.07 至 0.39）和 7-12 个月（SMD = 0.03，95% CI：-0.08 至 0.13）时，两组之间无差异。
我们的研究发现一些微弱的证据支持，与 BF-IOL 植入相比，UVF-IOL 植入仅在较短的时间内显示出对主观睡眠质量的更大改善，但在较长的时间内则没有。在提出进一步建议之前，应该进行更多的试验。然而，我们的研究为短波长电磁辐射对昼夜节律的影响提供了一些见解。PROSPERO 注册号：CRD42019128832。
