Department of Ophthalmology, Shanghai First People's Hospital Affiliated Shanghai Jiao Tong University, Shanghai, China.
PLoS One. 2012;7(3):e33013. doi: 10.1371/journal.pone.0033013. Epub 2012 Mar 7.
A number of published randomized controlled trials have been conducted to evaluate visual performance of blue light-filtering intraocular lenses (IOL) and UV light-filtering intraocular lenses (IOL) after cataract phacoemulsification surgery. However, results have not always been consistent. Therefore, we carried out a meta-analysis to compare the effectiveness of blue light-filtering IOLs versus UV light-filtering IOLs in cataract surgery.
Comprehensive searches of PubMed, Embase, Cochrane Library and the Chinese BioMedical literature databases were performed using web-based search engines. Fifteen trials (1690 eyes) were included for systematic review, and 11 of 15 studies were included in this meta-analysis. The results showed that there were no significant differences in postoperative mean best corrected visual acuity, contrast sensitivity, overall color vision, or in the blue light spectrum under photopic light conditions between blue light-filtering IOLs and UV light-filtering IOLs [WMD = -0.01, 95%CI (-0.03, 0.01), P = 0.46; WMD = 0.07, 95%CI (-0.04, 0.19), P = 0.20; SMD = 0.14, 95%CI (-0.33, 0.60), P = 0.566; SMD = 0.20, 95%CI (-0.04, 0.43), P = 0.099]. However, color vision with blue light-filtering IOLs was significantly reduced in the blue light spectrum under mesopic light conditions [SMD = 0.74, 95%CI (0.29, 1.18), P = 0.001].
This meta-analysis demonstrates that postoperative visual performance with blue light-filtering IOLs is approximately equal to that of UV light-filtering IOLs after cataract surgery, but color vision with blue light-filtering IOLs demonstrated some compromise in the blue light spectrum under mesopic light conditions.
已经进行了许多发表的随机对照试验，以评估白内障超声乳化手术后蓝紫光滤过型人工晶状体（IOL）和紫外光滤过型人工晶状体（IOL）的视觉性能。然而，结果并不总是一致的。因此，我们进行了一项荟萃分析，以比较蓝紫光滤过型 IOL 与紫外光滤过型 IOL 在白内障手术中的效果。
我们使用基于网络的搜索引擎对 PubMed、Embase、Cochrane 图书馆和中国生物医学文献数据库进行了全面检索。系统评价纳入了 15 项试验（1690 只眼），其中 11 项研究被纳入荟萃分析。结果显示，在术后平均最佳矫正视力、对比敏感度、整体色觉以及明视条件下的蓝光光谱中，蓝紫光滤过型 IOL 与紫外光滤过型 IOL 之间没有显著差异[加权均数差（WMD）=-0.01，95%置信区间（CI）（-0.03，0.01），P=0.46；WMD=0.07，95%CI（-0.04，0.19），P=0.20；标准化均数差（SMD）=0.14，95%CI（-0.33，0.60），P=0.566；SMD=0.20，95%CI（-0.04，0.43），P=0.099]。然而，在中视条件下，蓝紫光滤过型 IOL 的蓝光光谱中的色觉明显降低[SMD=0.74，95%CI（0.29，1.18），P=0.001]。
这项荟萃分析表明，白内障手术后蓝紫光滤过型 IOL 的术后视觉表现与紫外光滤过型 IOL 大致相当，但在中视条件下的蓝光光谱中，蓝紫光滤过型 IOL 的色觉存在一些缺陷。
