Department of Ophthalmology, University of Kansas School of Medicine, Prairie Village, Kansas, USA.
Vienna Institute for Research in Ocular Surgery, A Karl Landsteiner Institute, Hanusch Hospital, Vienna, Austria.
Am J Ophthalmol. 2022 Aug;240:51-57. doi: 10.1016/j.ajo.2022.02.016. Epub 2022 Feb 25.
The blue light hazard is the experimental finding that blue light is highly toxic to the retina (photic retinopathy), in brief abnormally intense exposures, including sungazing or vitreoretinal endoillumination. This term has been misused commercially to suggest, falsely, that ambient environmental light exposure causes phototoxicity to the retina, leading to age-related macular degeneration (AMD). We analyze clinical, epidemiologic, and biophysical data regarding blue-filtering optical chromophores.
Perspective.
Analysis and integration of data regarding the blue light hazard and blue-blocking filters in ophthalmology and related disciplines.
Large epidemiologic studies show that blue-blocking intraocular lenses (IOLs) do not decrease AMD risk or progression. Blue-filtering lenses cannot reduce disability glare because image and glare illumination are decreased in the same proportion. Blue light essential for optimal rod and retinal ganglion photoreception is decreased by progressive age-related crystalline lens yellowing, pupillary miosis, and rod and retinal ganglion photoreceptor degeneration. Healthful daily environmental blue light exposure decreases in older adults, especially women. Blue light is important in dim environments where inadequate illumination increases risk of falls and associated morbidities.
The blue light hazard is misused as a marketing stratagem to alarm people into using spectacles and IOLs that restrict blue light. Blue light loss is permanent for pseudophakes with blue-blocking IOLs. Blue light hazard misrepresentation flourishes despite absence of proof that environmental light exposure or cataract surgery causes AMD or that IOL chromophores provide clinical protection. Blue-filtering chromophores suppress blue light critical for good mental and physical health and for optimal scotopic and mesopic vision.
蓝光危害是指实验发现蓝光对视网膜(光性视网膜病变)具有高度毒性,简而言之,包括凝视太阳或玻璃体视网膜内照明在内的异常高强度暴露。这个术语在商业上被滥用,错误地暗示环境光暴露会对视网膜造成光毒性,导致年龄相关性黄斑变性(AMD)。我们分析了有关蓝光滤光光学色素的临床、流行病学和生物物理数据。
透视。
分析和整合眼科及相关学科中有关蓝光危害和蓝光阻断滤光片的数据。
大型流行病学研究表明,蓝光阻断人工晶状体(IOL)不会降低 AMD 的风险或进展。蓝光滤光镜片不能减少眩光干扰,因为图像和眩光照明会以相同的比例减少。随着年龄相关的晶状体变黄、瞳孔缩小和杆状和视网膜神经节感光细胞退化,对最佳杆状和视网膜神经节感光所必需的蓝光会逐渐减少。健康的日常环境蓝光暴露在老年人中减少,尤其是女性。蓝光在环境光不足的昏暗环境中很重要,因为这会增加跌倒和相关疾病的风险。
蓝光危害被滥用为营销策略,吓唬人们使用限制蓝光的眼镜和 IOL。对于具有蓝光阻断 IOL 的假眼,蓝光损失是永久性的。尽管缺乏证据表明环境光暴露或白内障手术会导致 AMD 或 IOL 色素提供临床保护,但对蓝光危害的错误描述仍在盛行。蓝光色素抑制了对身心健康以及最佳暗视觉和中间视觉至关重要的蓝光。