Wang Hogan, Roche Christopher D, Gentile Carmine
Northern Clinical School of Medicine, University of Sydney, Kolling Institute, St Leonards, Sydney, NSW, Australia.
Department of Cardiothoracic Surgery, Royal North Shore Hospital, St Leonards, Sydney, NSW, Australia.
Eur J Cardiothorac Surg. 2020 Dec 1;58(6):1118-1129. doi: 10.1093/ejcts/ezaa205.
Preclinical in vivo studies using omental tissue as a biomaterial for myocardial regeneration are promising and have not previously been collated. We aimed to evaluate the effects of the omentum as a support for bioengineered tissue therapy for cardiac regeneration in vivo.
A systematic scoping review was performed. Only English-language studies that used bioengineered cardio-regenerative tissue, omentum and ischaemic cardiomyopathy in vivo models were included.
We initially screened 1926 studies of which 17 were included in the final qualitative analysis. Among these, 11 were methodologically comparable and 6 were non-comparable. The use of the omentum improved the engraftment of bioengineered tissue by improving cell retention and reducing infarct size. Vascularization was also improved by the induction of angiogenesis in the transplanted tissue. Omentum-supported bioengineered grafts were associated with enhanced host reverse remodelling and improved haemodynamic measurements.
The omentum is a promising support for myocardial regenerative bioengineering in vivo. Future studies would benefit from more homogenous methodologies and reporting of outcomes to allow for direct comparison.
使用网膜组织作为心肌再生生物材料的临床前体内研究前景广阔，且此前尚未进行整理。我们旨在评估网膜作为体内心脏再生生物工程组织治疗支持物的效果。
进行了一项系统的范围综述。仅纳入了在体内模型中使用生物工程心脏再生组织、网膜和缺血性心肌病的英文研究。
我们最初筛选了1926项研究，其中17项纳入了最终的定性分析。其中，11项在方法上具有可比性，6项无可比性。网膜的使用通过改善细胞保留和减小梗死面积，提高了生物工程组织的植入率。移植组织中血管生成的诱导也改善了血管化。网膜支持的生物工程移植物与增强的宿主逆向重塑和改善的血流动力学测量相关。
网膜是体内心肌再生生物工程的一个有前景的支持物。未来的研究将受益于更统一的方法和结果报告，以便进行直接比较。
