三维生物打印心脏组织用于心脏手术的当前挑战。
Current challenges in three-dimensional bioprinting heart tissues for cardiac surgery.
机构信息
Northern Clinical School of Medicine, University of Sydney, Kolling Institute, St Leonards, Sydney, NSW, Australia.
Department of Cardiothoracic Surgery, Royal North Shore Hospital, St Leonards, Sydney, NSW, Australia.
出版信息
Eur J Cardiothorac Surg. 2020 Sep 1;58(3):500-510. doi: 10.1093/ejcts/ezaa093.
Previous attempts in cardiac bioengineering have failed to provide tissues for cardiac regeneration. Recent advances in 3-dimensional bioprinting technology using prevascularized myocardial microtissues as 'bioink' have provided a promising way forward. This review guides the reader to understand why myocardial tissue engineering is difficult to achieve and how revascularization and contractile function could be restored in 3-dimensional bioprinted heart tissue using patient-derived stem cells.
以往在心脏生物工程方面的尝试均未能提供用于心脏再生的组织。最近，利用预先形成血管的心肌微组织作为“生物墨水”的 3 维生物打印技术的进步为我们提供了一个很有前景的方法。本综述引导读者了解心肌组织工程为何难以实现，以及如何使用患者来源的干细胞在 3 维生物打印的心脏组织中恢复血管生成和收缩功能。
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